BIOPHYS STUD OF PROTEINS, NUCLEIC ACIDS, AND VIRUSES

普渡大学的生物物理培训补助金继续强调结构生物学，同时增加了涉及和影响结构生物学的其他学科的教师导师的代表性。在此期间，指导教师从19人增加到22人，来自六个不同部门的所有成员都完全或部分参与了结构生物学的某些方面。两个新部门的代表，并从生物，生物化学和物理导师的数量增加。基本的核心研究设备，X射线衍射仪，核磁共振光谱仪和电子显微镜，有了很大的扩展和改进。重叠的研究兴趣的六个领域（可溶性蛋白质，膜蛋白和毒素，核酸结构功能和蛋白质-核酸相互作用，病毒结构功能，计算方法和金属蛋白）可以确定与至少四名教师的最小教师集群大小。这些互动导致了五十三个出版物涉及至少两名教员在两个赠款期间，其中13名生物物理学实习生也参加了。在此期间，过去和现在的生物物理学为132篇出版物和演讲和专业会议摘要做出了贡献。很大一部分过去的受训人员目前正在大学或工业界积极从事研究工作。在上一个赠款期间，来自代表性不足的少数民族和妇女的受训者人数很多。一个关于伦理和科学的重要问题的讨论小组，涉及学生和教师，受到了热烈的欢迎。研究生课程的课程已经改善，并保持了高度重视定量。该计划的新教育方面是每年面向学生的生物物理研讨会，已经提出了三次，以及研讨会前的“生物物理讨论”，由不同的导师在即将举行的研讨会上提出的中心概念。每周一次的结构生物学研讨会和双周一次的结构生物学期刊俱乐部仍然是定期的研究和培训活动。

The biophysical training grant at Purdue University has continued its strong emphasis on structural biology, while increasing the representation of faculty mentors from other disciplines which involve and affect structural biology. The mentoring faculty has increased from 19 to 22 in this period, with all members from six different departments either fully or partly involved in some aspect of structural biology. Two new departments are represented, and the number of mentors from biology, biochemistry, and physics as increased. The basic core research equipment, X-ray diffractometers, NMR spectrometers, and electron microscopes, has expanded and improved greatly. Six areas of overlapping research interests (structure-function of soluble proteins, membrane proteins and toxins, nucleic acid structure-function and protein-nucleic acid interactions, virus structure-function, computational approaches and metalloproteins) can be identified with a minimum faculty cluster size of at least four faculty members. These interactions had led to fifty-three publications involving at least two faculty members over the two grant periods in which thirteen biophysics trainees have also participated. During this time, past and current biophysics have contributed to 132 publications and abstracts of presentations and professional meetings. A high fraction of past trainees are currently working actively in research at universities or in industry. During the last grant period, there has been important and significant representation among the trainees from under-represented minorities and women. A discussion group on important issues of ethics and science, involving both students and faculty, has been enthusiastically received. The graduate course curriculum has improved and maintained a high degree of emphasis on quantitation. New educational aspects of the program have been an annual-student oriented biophysics symposium, already presented three times, and pre-seminar "biophysical discussions" given by different mentors on central concepts to be presented in upcoming seminars. The weekly structural biology seminars and bi-weekly structural biology journal club have continued to be regular research and training events.