ASTHMA ETIOLOGY

建议的哮喘病因学项目的长期目标 哥伦比亚儿童环境健康中心将 阐明出生前和2岁以下的暴露对 蟑螂、尘螨和啮齿动物过敏原与环境 有毒物质、可吸入颗粒物(PM/2.5)、柴油废气 变应原中的颗粒物(DEP)和环境烟草烟雾(ETS) 过敏和反复喘息。变应原致敏和复发 喘息已被发现是哮喘的早期预测因素。目前， 对出生前和出生后早期的影响知之甚少。 环境暴露对过敏原致敏和反复喘息的影响 2岁之前。我们研究的假设是：1)过敏原的风险 2岁前过敏和反复喘息增加 环境暴露于蟑螂、尘螨和啮齿动物过敏原和 对PM/2.5、DEP和ETS的影响；2)过敏原暴露对 暴露于空气中会增加过敏原过敏和反复喘息 PM/2.5、DEP和/或ETS；以及3)检验低血浆假设 抗氧化性微量营养素(维生素A、C、E)的水平会增加 婴儿对过敏原的易感性，使其产生不良影响 抗氧化剂含量低的儿童过敏原含量更高 微量营养素。该项目的成果将促进知识的发展 关于过敏原致敏和复发的早期生命危险因素 喘息和哮喘的发作。

The long-term objective of the asthma etiology project of the proposed Columbia Center for Children's Environmental Health (CCCEH) is to elucidate the role of exposures, before birth and up to age 2, to cockroach, dust mite and rodent allergens and to the environmental toxicants, respirable particulate matter (PM/2.5), diesel exhaust particulate (DEP) and environmental tobacco smoke (ETS), in allergen sensitization and recurrent wheezing. Allergen sensitization and recurrent wheezing have been found to be early predictors of asthma. Currently, little is known about the effects of prenatal and early postnatal environmental exposures on allergen sensitization and recurrent wheezing before age 2. Our study's hypotheses are that 1) the risks for allergen sensitization and recurrent wheezing before age 2 are increased be environmental exposures to cockroach, dust mite, and rodent allergens and to PM/2.5, DEP and ETS; 2) the adverse effect of allergen exposure on allergen sensitization and recurrent wheezing is increased by exposure to PM/2.5, DEP and/or ETS; and 3) To test the hypothesis that low plasma levels of antioxidant micronutrients (vitamins A, C, E) increase the infant's susceptibility to allergens, so that the adverse effects of allergens are greater for children with low levels of antioxidant micronutrients. The results of the Project will advance the knowledge about early-life risk factors for allergen sensitization and recurrent wheezing and the onset of asthma.