Core--Training

在超级基金场址及其渗滤液中发现的化学污染物可能在导致人类疾病和生态系统健康恶化方面发挥重要作用。因此，这种疾病和生态退化是可以预防的，只要这些因素可以确定并从环境中消除或抵消。认识到这种可能性，就需要加紧努力，查明因果因素，确定调节其生物利用度的条件，阐明其作用机制，并制订适当措施，阻止或扭转其影响。该计划的目的是提供培训，为环境毒理学领域的科学家提供积极和富有成效的职业生涯，重点是环境工程，生物修复，生态学和生物医学研究。其目的是使受训者准备好计划、进行和解释毒理学研究，这些研究适合于有关超级基金污染物对人类和野生动物种群的命运和影响的具体科学问题。这个项目的范围很广。例如，将向学员提供背景知识，使他们能够研究影响金属和芳香烃对人类和鱼类对环境引起的疾病易感性变化的遗传和表观遗传因素，并了解影响这些污染物在生态系统中生物利用度的那些因素。该项目提供2个博士预科和4个实习岗位。

Chemical contaminants found at Superfund sites and in their leachates may play a significant role in the causation of human disease and in the deterioration of ecosystem health. Thus, such disease and ecological degradation is preventable to the extent that such factors can be identified and either removed from the environment or counteracted. Recognition of this possibility requires intensified efforts to identify the causal factors, to determine those conditions which modulate their bioavailabilities, to elucidate their mechanisms of action and to formulate appropriate measures for blocking or reversing their effects. The purpose of this Program is to provide training to prepare scientists for active and productive careers in environmental toxicology with interdisciplinary emphases on environmental engineering, bioremediation, ecology, and biomedical research. The objective is to prepare the trainees to plan, conduct, and interpret toxicological studies which are appropriate to specific scientific issues regarding the fate and effects of Superfund contaminants on human and wildlife populations. The scope of this program is broad. For example, trainees will be provided with backgrounds enabling them to study genetic and epigenetic factors which impact variation in susceptibilities to environmentally-induced disease in humans and in fish by metals and aromatic hydrocarbons and to understand those factors which influence bioavailabilities of these contaminants in ecosystems. The program provides for two predoctoral (Ph.D.) And four internship positions.