CORE--Molecular genetics and environmental carcinogenesis

描述：这个核心由谢丽尔·沃克博士执导，由15个 成员，其中四人在核心中担任次要任命。初选中的两个 会员是中心的准会员，其中一人是附属会员。 自上一次审查以来，这一核心被命名为“影响 环境因素对细胞生长和分化的影响“，三名成员 离开了学院，其中一个人将他的从属关系从核心3改为核心1，1 由于缺乏参与，成员资格被终止，还有三个 个人似乎被招募为新成员。这样做的目的是 核心是促进CRID调查人员之间的互动研究，以定义 细胞和分子对环境暴露的反应并确定 这些反应可变性的遗传基础。为了实现这一目标， 提出了四个具体目标：1)作为 CRID调查人员之间的多学科合作研究 遗传易感性领域，使用基因定义的动物模型，以及 新兴分子技术；2)通过以下方式支持核心研究 互动式讨论论坛，赞助外部研讨会演讲者，以及 试点项目；3)促进初级教师队伍的发展，鼓励 招募个人进入中心，他们将与此进行互动 核心？S活动；4)为核心3的利益发声 在更大的信誉内的成员，并作为唯一贡献的渠道 将3个核心专业知识转移到中心。 分子遗传学和环境致癌核心拥有280万 当前赠款支持的美元(NIEHS支持34万美元) 另有100万美元待定。现有和待定拨款中的几个 应用程序涉及新的协作努力。此外，一个新的计划， 项目赠款最近授予了核心3调查人员中的一名 这也涉及到核心和中间派的其他人。Research Core 3作为 一份完整的季刊，但也赞助了一份更有针对性的期刊 俱乐部。他们一直活跃在COEP活动中，并大量使用除 分析仪器服务核心。 对这一研究核心的未来计划的描述强调了重点 努力促进围绕以下三个中心主题的合作研究 核心，即遗传易感性，遗传定义的模型系统，以及 新兴技术。

Description: This core is directed by Dr. Cheryl Walker and consists of 15 members, four which hold secondary appoints in the core. Two of the primary members are Associate Members of the Center while one is an Affiliate Member. Since the last review, at which time this core was entitled, "Impact of Environmental Agents on Cell Growth and Differentiation", three members have left the institution, one changed his affiliation from Core 3 to Core 1, one membership was terminated due to a lack of participation, and three individuals appear to have been recruited as new members. The goal of this core is to foster interactive research between CRED investigators to define cellular and molecular responses to environmental exposures and identify the genetic basis for variability in those responses. To accomplish this goal, four specific aims are proposed: 1) to serve as a catalyst for multidisciplinary, collaborative research between CRED investigators in the areas of genetic susceptibility, use of genetically defined animal models, and emerging molecular technologies; 2) to support core research efforts through interactive discussion forums, sponsorship of outside seminar speakers, and pilot projects; 3) to promote the advancement of junior faculty and encourage the recruitment of individuals into the center who would interact with this Core?s activities; and 4) To serve as a voice for the interests of Core 3 members within the larger CRED and as a conduit for contribution of unique Core 3 expertise to the Center. The Molecular Genetics and Environmental Carcinogenesis Core holds 2.8 million dollars in current grant support (0.34 million in NIEHS support) with an additional 1.0 million pending. Several of the existing and pending grant applications involve new collaborative efforts. In addition, a new program project grant has recently been awarded to one of the Core 3 investigators that also involves others from the core and Center. Research Core 3 meets as a whole on a quarterly basis, but also has sponsored a more focused journal club. They have been active in COEP activities and are heavy users of all but the Analytical Instrumentation Service Core. A description of future plans for this Research Core emphasized focused efforts on promoting collaborative research along the three central themes of the core, i.e., genetic susceptibility, genetically defined model systems, and emerging technologies.