Elucidation of the Mechanism of IL-22-Mediated Suppression of β-Cell Stress in Diabetes

胰腺β细胞产生控制血糖的激素胰岛素。2型糖尿病的特点是应激β细胞不能产生足够的胰岛素来控制血糖。我们发现一种免疫因子，IL-22，可以保护β细胞免受压力。用IL-22治疗糖尿病小鼠解决了糖尿病的所有主要问题。该项目旨在揭示IL-22保护β细胞免受应激的机制，具有开发新型糖尿病治疗方法的潜力。

Pancreatic β-cells produce the hormone insulin that controls blood sugar. Type 2 diabetes is characterized by inability of stressed β-cells to make sufficient insulin to control blood sugar. We discovered that an immune factor, IL-22, protects β-cells from stress. Treatment of diabetic mice with IL-22 resolves all the major problems in diabetes. This project seeks to reveal the mechanisms by which IL-22 protects β-cells from stress, with potential for development of novel diabetes therapies.