Development of defect models for the ankle to evaluate changes in joint geometry and tribology as a predictor for degeneration

该项目的目的是开发临床相关的实验和/或计算模型来代表踝关节骨缺损，以探索对力学和摩擦学的影响，以确定潜在的退变途径。目的：1)识别与骨缺陷相关的踝关节几何变化识别典型的“正常”距骨几何变化识别与血友病相关的缺陷（典型的关节表面几何）骨软骨缺陷（位置和大小/形状）相关的几何变化2)识别骨力学特性的变化。力学描述的组织(可用)计算模型基于医学imaging3)代表的发展缺陷模型(使用数据从1 & 2)调查的方法开发的尸体骨骨'Biochemical退化变性tissue3D talar模型代表印刷缺陷和骨structureComputational有限元模型的脚踝joint4)调查的影响缺陷的摩擦学踝关节在适当的范围条件（实验和/或计算）静态负载（接触压力，例如Tekscan）在自然关节模拟器中的实验测试（疲劳，摩擦，磨损）研究参数范围的有限元模型自然踝关节几何特征开发针对踝关节的新型实验和/或计算方法有限的自然踝关节建模实验或计算已经进行了迄今为止。因此，这个项目代表了生物工程在开发预测退化模型方面的重大进步。未来治疗发展的潜在平台

The aim of this project is to develop clinically relevant experimental and/or computational models to represent bony defects of the ankle, in order to explore the influence on mechanics and tribology to identify a potential degeneration pathway.Objectives:1)To identify the geometric changes in the ankle relating to bony defectsidentify typical 'normal' talar geometryIdentify changes in geometry relating:Haemophilia related defects (typically joint surface geometry)Osteochondral defect (location and size/shape)2)To identify changes in mechanical properties of the bone. Mechanical characterisation of tissues (where available)Computational modelling based on medical imaging3)Development of representative defect models (using data from 1 & 2)Investigation of methods for developing 'degraded bone'Biochemical degeneration of cadaveric bone tissue3D printing of talar models with representative defects and bony structureComputational FE models of the ankle joint4)To investigate the effect of defects on the tribology of the ankle joint under a range of appropriate conditions(experimentally and/or computationally)static loading (contact pressure e.g. Tekscan)experimental testing in a natural joint simulator (fatigue, friction, wear) Finite element models to investigate range of parametersCharacterisation of the geometry of the natural ankleDevelopment of novel experimental and/or computational methods focussed on the ankle jointLimited natural ankle modelling either experimentally or computationally has been undertaken to date, and therefore this project represents a significant bioengineering advance in the ability to develop a model for predicting degeneration.Potential platform for future treatment development