Functional highly ordered mesoporous phosphate glasses prepared by sol-gel

目的：-通过溶胶-凝胶途径生产用于生物医学应用的多孔磷酸盐玻璃材料。孔隙度将允许药物装载和释放。-探索其他软化学途径生产磷酸盐玻璃。-在玻璃中加入银、铜、锌等金属离子，探索不同的玻璃成分。许多金属离子已被证明在伤口愈合和骨生成机制中发挥重要作用，而银等其他离子已被证明具有抗菌特性。-研究生产的玻璃的物理和化学性质，如生物相容性、抗菌性、溶解性、强度和化学稳定性。方法：-使用表面活性剂作为模板剂，生产纳米级有孔的玻璃。表面活性剂将在生产后离开孔隙被去除。-多孔支架将使用静电纺丝生产。这将允许更大的表面积和更高的载药能力。

Aims:- To produce porous phosphate glass materials via the sol-gel route for the use in biomedical applications. The porosity will allow for drug loading and release.- To explore other soft-chemistry routes to produce phosphate glasses.- To explore different glass compositions by incorporating various metal ions into the glasses such as silver, copper and zinc. Many metal ions have been shown to play important roles in the wound healing and bone-production mechanisms and other ions such as silver have been presented as possessing antibacterial properties.- To study the physical and chemical properties of glasses produced such as biocompatibility, antibacterial properties, dissolution, strength and chemical stability.Methodology:- Produce glasses with pores on the nanoscale with the use of surfactants as templating agents. The surfactants will be removed after production leaving pores.- Porous scaffolds will be produced with the use of electrospinning. This will allow for a larger surface area and higher drug-loading capacities.