COMPLEX BRAIN BEHAVIOR RELATIONS IN ALCOHOL STUDIES

申请人摘要：这是一份独立科学家奖的申请书 (KO2)扩大申请人对酒精相关疾病的研究计划， 神经心理损伤和治疗结果。 目的是发展一个 多层次的神经科学方法来研究这些复杂的大脑行为 通过开展专业合作和高级培训， 定量和神经成像方法。 第一个职业目标是 进一步发展以复杂变量为中心和以人为中心的专业知识 定量方法，以及整合这两个分析方法， 接近。将通过以下方式培养专业的定量技能： 与专家合作并参加高级培训机构。 这些技能将用于测试复杂的调解和适度模型， 酒精相关神经心理损害对治疗的影响 三个现有的NIAAA和私人数据库的结果。 第二职业 目的是获得磁共振成像（MRI）的专业知识， 功能性磁共振成像（fMRI）方法。 神经影像学的职业发展将 包括正式的课程工作，实践培训，以及与 专家 神经影像学培训将应用于对 酒精中毒和抑郁症家族史对抑郁症的影响 青少年神经心理障碍和神经解剖学变化 精神病诊断与对照组相比， 诊断。 神经认知脆弱性和症状增强的假设 将测试高风险FH+青年的严重程度。

APPLICANT'S ABSTRACT: This is a proposal for an Independent Scientist Award (KO2) to expand the applicant's research program on alcohol-associated neuropsychological impairment and treatment-outcome. The aim is to develop a multilevel neuroscience approach for studying these complex brain-behavior relations by pursuing specialized collaboration and advanced training in quantitative and neuroimaging methodologies. The first career objective is to develop further expertise in complex variable-centered and person-centered quantitative methods, as well as methods for integrating these two analytic approaches. Specialized quantitative skills will be developed through collaboration with experts and participation in advanced training institutes. These skills will be used to test complex mediation and moderation models of the effects of alcohol-related neuropsychological impairment on treatment outcomes in three existing NIAAA and private data bases. The second career objective is to gain expertise in magnetic resonance imaging (MRI) and functional MRI (fMRI) methods. Career development in neuroimaging will comprise formal course work, hands-on training, and collaboration with experts. Neuroimaging training will be applied to a preliminary study of the influence of family histories of alcoholism and depression on neuropsychological impairment and neuroanatomical changes in youth with psychiatric diagnoses compared to a control group with no psychiatric diagnoses. Hypotheses of heightened neurocognitive vulnerability and symptom severity in high-risk FH+ youth will be tested.