COMPLEX BRAIN BEHAVIOR RELATIONS IN ALCOHOL STUDIES

申请者摘要：这是一个设立独立科学家奖的建议 (KO2)扩大申请者关于酒精相关的研究计划 神经心理损伤和治疗--结果。其目标是开发一种 用多层次神经科学方法研究这些复杂的脑行为 通过寻求专业合作和高级培训 定量和神经成像方法。第一个职业目标是 进一步发展以复杂变量为中心和以人为中心的专业知识 定量方法，以及整合这两种分析的方法 接近了。将通过以下途径培养专门的量化技能 与专家合作，参加高级培训机构。 这些技能将用于测试复杂的调解和协调模型 酒精相关性神经心理损害对治疗的影响 三个现有的NIAAA和私人数据库的结果。第二职业 目标是获得磁共振成像(MRI)和 功能磁共振成像(FMRI)方法。神经成像领域的职业发展将 包括正式课程工作、动手培训以及与 专家。神经影像训练将被应用于初步研究 酗酒和抑郁家族史对精神分裂症的影响 青少年精神分裂症患者的神经心理障碍和神经解剖学改变 精神疾病诊断与没有精神疾病的对照组的比较 诊断。神经认知易损性和症状增高的假说 将对高危FH+青年的严重性进行测试。

APPLICANT'S ABSTRACT: This is a proposal for an Independent Scientist Award (KO2) to expand the applicant's research program on alcohol-associated neuropsychological impairment and treatment-outcome. The aim is to develop a multilevel neuroscience approach for studying these complex brain-behavior relations by pursuing specialized collaboration and advanced training in quantitative and neuroimaging methodologies. The first career objective is to develop further expertise in complex variable-centered and person-centered quantitative methods, as well as methods for integrating these two analytic approaches. Specialized quantitative skills will be developed through collaboration with experts and participation in advanced training institutes. These skills will be used to test complex mediation and moderation models of the effects of alcohol-related neuropsychological impairment on treatment outcomes in three existing NIAAA and private data bases. The second career objective is to gain expertise in magnetic resonance imaging (MRI) and functional MRI (fMRI) methods. Career development in neuroimaging will comprise formal course work, hands-on training, and collaboration with experts. Neuroimaging training will be applied to a preliminary study of the influence of family histories of alcoholism and depression on neuropsychological impairment and neuroanatomical changes in youth with psychiatric diagnoses compared to a control group with no psychiatric diagnoses. Hypotheses of heightened neurocognitive vulnerability and symptom severity in high-risk FH+ youth will be tested.