Compulsive Drug-Related Behavior & Classical Condition

拟议研究的目标是找出与经典 可能导致快速升级和强制性的条件反射 在人类吸毒者中观察到的吸毒和寻求毒品行为。第一 将检验药物相关刺激的能力 吸引生物体，引出接近和接触行为。这 实验将探索与自动成形(Brown)相关的变量 &Jenkins，1968)，以可卡因为增强剂。第二个实验将 确定药物相关刺激引起的行为在多大程度上 强迫性的，对工具性突发事件不敏感的。一次遗漏训练 程序(例如，Williams&Williams，1969)将在接近和 接触与药物配对的刺激会导致增强作用的丧失。三分之一 实验将检验药物相关行为的能力 刺激，以提高寻求毒品和吸毒行为的比率。这将是 通过使用行为对比程序来完成(雷诺兹，196 1)，其中 应对措施将由可卡因自我管理来维持。

The goal of the proposed research is to identify variables related to classical conditioning that may contribute to the rapid escalation and compulsivity of drug-taking and drug-seeking behavior observed in human drug abusers. The first of the proposed experiments will examine the ability of drug-associated stimuli to attract the organism and elicit approach and contact behavior. This experiment will explore the variables relevant to producing auto shaping (Brown & Jenkins, 1968) with cocaine as the reinforcer. A second experiment will determine the extent to which behavior elicited by drug-associated stimuli is compulsive and insensitive to instrumental contingencies. An omission training procedure (e.g., Williams & Williams, 1969) will be used where approaching and contacting the drug-paired stimulus results in a loss of reinforcement. A third experiment will examine the ability of behavior elicited by drug-associated stimuli to enhance rates of drug-seeking and drug-taking behavior. This will be accomplished by using a behavioral contrast procedure (Reynolds, 196 1), where responding will be maintained by cocaine self-administration.