First Meeting of the American Society for Matrix Biology

描述（由申请人提供）：细胞外基质（ECM）强烈影响正常生理和疾病中的细胞行为和组织稳态。ECM的组分在多种疾病中具有关键作用，包括颅面发育疾病、肌肉-骨骼系统疾病、肿瘤进展和肿瘤细胞转移、血管系统疾病和感染性疾病。ECM在胚胎的许多发育过程中也起着关键作用。 美国基质生物学协会（ASMB）的成立表明了ECM生物学和细胞基质相互作用领域的发展和新的重要性。ASMB的第一次会议定于2002年11月6日至9日在德克萨斯州休斯顿的万豪广场酒店举行。目标受众包括医生、学术科学家和工业研究人员以及研究生和博士后研究员。 主题演讲将讨论关键分泌分子的作用，这些分子控制许多发育决定，包括颅面发育，骨骼发育和牙齿形成。在全体会议上的讲座将讨论广泛的机制概念，ECM控制细胞行为的关键方面，在胚胎发育过程中，在器官的正常生理功能和疾病。这些会议将包括对ECM的组装和重塑，ECM向细胞发出信号的复杂机制，ECM如何控制细胞迁移和运动以及影响细胞分化和命运的讨论。在这些会议中讨论的概念将基于具体的例子，包括肌肉骨骼和皮肤疾病，血管发生疾病，癌症进展，神经细胞发育和胚胎发育的研究。下午的分组会议将扩展这些概念，并讨论ECM成分的结构生物学进展，ECM在感染和宿主防御中的作用，细胞粘附，控制血管形成，骨骼发育和慢性退行性疾病。该计划具有广泛的影响，与几个NIH研究所的任务密切相关，包括NIDCR，NIAMS，NHLBI，NCI，NICHDI，NINDS和NIA。 我们预计ASMB会议将每两年举行一次，在不久的将来，协会将能够为这些研讨会提供财政支持。然而，在第一次会议上，我们完全依靠外部支持。我们要求NIH为第一次会议提供40，000美元的支持。

DESCRIPTION (provided by applicant): The extracellular matrix (ECM) strongly influences cell behavior and tissue homeostasis, both in normal physiology and disease. Components of the ECM have critical roles in a variety of diseases including diseases of craniofacial development, diseases of the muscular-skeletal system, tumor progression and tumor cell metastasis, diseases of the vascular system and infectious diseases. The ECM also plays a pivotal role in many developmental processes in the embryo. The recent founding of the American Society for Matrix Biology (ASMB) demonstrates the growth and new importance of the field of ECM biology and cell matrix interactions. The first meeting of the ASMB is scheduled to take place at the Marriott Galleria Hotel, Houston, TX, Nov 6-9, 2002. The target audience is composed of physicians, academic scientists and industrial researchers, as well as graduate students and postdoctoral fellows. The Keynote address will discuss the role of key secreted molecules, which control many developmental decisions including craniofacial development, skeletal development, and tooth formation. Lectures in the plenary sessions will discuss broad concepts of the mechanisms by which the ECM controls critical aspects of cell behavior during embryo development in the normal physiological functions of organs and in diseases. These sessions will include discussions on the assembly and remodeling of the ECM, the complex mechanisms by which the ECM signals to cells, how the ECM controls cell migration and motility and influences cell differentiation and fate. The concepts discussed in these sessions will be based on specific examples including studies of muscular-skeletal and skin disease, diseases of vasculogenesis, cancer progression, neuronal cell development, and embryo development. Breakout afternoon sessions will expand on these concepts and discuss progress in structural biology of ECM components, the role of the ECM in infection and host defense, in cell adhesion, in the control of blood vessel formation, in skeletal development and in chronic degenerative diseases. The program has broad implications that are closely related to the missions of several NIH institutes, including NIDCR, NIAMS, NHLBI, NCI, NICHDI, NINDS, and NIA. We anticipate that the ASMB meeting will occur on a biennial basis and the society in the near future will be able to financially support these symposia. However, for the initial meeting, we rely entirely on outside support. We are requesting $40,000 in NIH support for the 1st meeting.