THE WEINSTEIN CONFERENCE ON CARDIOVASCULAR DEVELOPMENT

描述（申请人的描述逐字）：部分支持是 要求为正在进行的年度“温斯坦会议， 心血管发育。“本次会议由 康斯坦斯·温斯坦博士以前的NHLBI工作人员，致力于 目标是了解潜在的分子和细胞生物学机制， 脊椎动物心血管发育。在过去的五年里， 250-300名与会者已成为心血管领域的首要会议 发展和汇集了来自主要和不同的代表 在该领域工作的实验室。本次会议是在 “温斯坦会议委员会”是一个常设组织， 制定了章程，由该领域的领导者组成，并轮流担任 温斯坦委员会成员所在机构的不同地点。 会议的具体目标是：（一）交流基本成果， 关于特定基因及其 蛋白质产物介导心脏和血管的发育， 心脏形态发生和异常发育的人类和动物模型 导致先天性心脏病、心肌病和心律失常。(ii)到 促进基础实验室和临床科学家的互动 参与诊断和评估人类缺陷的专业， 心血管发展，以鼓励合作的方法， （iii）鼓励年青调查员投身调查工作， 涉及心血管发育。口头会议的主题包括 心脏形态学，心脏功能，人类心血管缺陷的遗传学， 实验心血管胚胎学，肌细胞结构和组织， 调节心血管系统中的基因表达， 心血管疾病的无效小鼠模型。最近的爆炸， 描绘正常心脏和血管发育所必需的基因， 发现人类和鼠基因中的突变引起异常的 心血管发展强调了这些会议的及时性。NIH 支持将使学生和研究员更容易获得， 稳定这些会议的逐年规划， 妇女和少数民族的代表人数达到与会者人数。

DESCRIPTION (the applicant's description verbatim): Partial support is requested for 3 years for the ongoing annual "Weinstein Conference on Cardiovascular Development." This meeting, established and coordinated by Constance Weinstein, Ph.D., formerly of the NHLBI staff, is dedicated to the goal of understanding the molecular and cell biological mechanisms underlying vertebrate cardiovascular development. Over the last 5 years, this meeting of 250-300 participants has become the premier conference on Cardiovascular Development and brings together representatives from the major and diverse laboratories working in this area. The meeting is organized under direction of the "Weinstein Conference Committee," a permanent organization with an established Charter and composed of leaders in this field, and rotates to different sites at the home institutions of members of the Weinstein Committee. The specific aims for the meeting are (i) to communicate results of basic investigation concerning the mechanisms by which specific genes and their protein products mediate cardiac and vascular development both in normal cardiac morphogenesis and in humans and animal models of aberrant development resulting in congenital heart disease, cardiomyopathy, and arrhythmias. (ii) to promote interactions of scientists from basic laboratories and clinical specialties involved in diagnosis and evaluation of humans with defects in cardiovascular development to encourage collaborative approaches to investigation, and (iii) to encourage young investigators to pursue careers involved cardiovascular development. Topics presented at oral session include cardiac morphology, cardiac function, genetics of human cardiovascular defects, experimental cardiovascular embryology, myocyte structure and organization, regulation of gene expression in the cardiovascular system, and transgenic and null mouse models of cardiovascular disease. The recent explosion in delineation of genes essential for normal cardiac and vascular development and discovery of mutations in human and murine genes causing aberrant cardiovascular development emphasizes the timeliness of these conferences. NIH support would provide increased accessibility for students and fellows, stabilization of year to year planning for these meetings, and increase representation of women and minorities amount conference participants.