Novel bioimaging analytical methods

描述（由申请人提供）：本提案的目的是证明一种改进生物分子成像方法性能的新方法的可行性。一项新技术可以提高信噪比，节省昂贵的试剂，减少分析生物成像技术的分析时间。这种独特的方法以前从未被用于改善这些方法的性能。我们建议进一步改进和优化新技术，以产生适合研究和临床实践的常规技术。提高生物分子成像测定的灵敏度而不损害准确性是至关重要的。新技术可用于成像细胞中的蛋白质表达。因此，我们的建议具有诊断和筛选相关的目标，并将新的工程原理应用于生物学和医学问题。

DESCRIPTION (provided by applicant): The objective of this proposal is to demonstrate the feasibility of a new approach to improving the performance of bio-molecular imaging methods. A new technology allows one to increase the signal-to-noise ratio, save costly reagents and reduce time of analysis of analytical bio-imaging techniques. This unique approach has never been used before for improvement of the performance of these methods. We propose to further improve and optimize the new technology, so as to generate routine technique suitable for research and clinical practice. Increasing sensitivity of bio-molecular imaging assays without compromising accuracy is of utmost importance. New technology can be used for imaging protein expression in cells. Thus, our proposal has diagnosis- and screening -related goals and applies new engineering principles to problems in biology and medicine.