HARVESTING AUTOLOGOUS GROWTH FACTORS FOR SURGICAL USE

性状（由申请方提供）：重组和自体生长因子 愈合剂越来越多地用于临床和外科伤口 治愈的场景重组生长因子在治疗上应用于 治愈顽固性糖尿病和静脉溃疡，而自体生长因子， 用于主要的整形外科应用，例如脊柱融合和关节 植入物.然而，当前增长的成本和/或不便 以生产要素为基础的产品阻碍了它们的广泛使用。外科的未来 因此，生长因子修复剂将取决于自体移植的容易程度。 可以获得增长因子，并显著降低成本。 认识到这一点，申请人设计了一个快速，方便 和相对便宜的自体血小板的术中收获 保存的生长因子。该提案中描述的新系统 避免了离心分离的需要，并且它可以，第一次， 从少量血液中常规收获自体生长因子 在手术中。通过该过程收获血小板可以允许 使用多种经批准的底物递送生长因子， 水凝胶、胶原蛋白组合物、藻酸盐等。 本发明的概念是使自体生长因子易于用于 各种软硬组织手术应用。 拟定商业应用：拟议的项目将导致开发一种方便，快速和廉价的方法来分离自体生长因子，这些生长因子可以在各种软组织和硬组织外科手术中用于增强伤口愈合。

DESCRIPTION (provided by applicant): Recombinant and autologous growth factor healants are being utilized increasingly for clinical and surgical wound healing scenarios. Recombinant growth factors are therapeutically applied to heal intractable diabetic and venous ulcers, while autologous growth factors are used in major orthopedic applications such as spinal fusion and joint implants. However, the cost and/or inconvenience of the current growth factor-based products have impeded their widespread use. The future of surgical growth factor healants will thus depend on the ease with which autologous growth factors can be obtained, and significant cost reduction. Recognizing this, the applicants have designed a process for quick, convenient and relatively inexpensive intraoperative harvesting of autologous platelets with preserved growth factors. The novel system described in this proposal obviates the need for centrifugation, and it can, for the first time, enable routine harvesting of autologous growth factors from small volumes of blood during surgery. The harvesting of platelets by this process can allow the delivery of growth factors using a wide variety of approved substrates such as hydrogels, collagen compositions, alginates etc. The eventual goal of this concept is to make autologous growth factors readily available for use in a wide variety of soft and hard tissue surgical applications. PROPOSED COMMERCIAL APPLICATION: The proposed project will lead to the development of a convenient, quick and inexpensive process to isolate autologous growth factors that can be delivered to augment wound healing in various soft and hard tissue surgical procedures.