HARVESTING AUTOLOGOUS GROWTH FACTORS FOR SURGICAL USE

说明书(申请人提供)：重组和自体生长因子 愈来愈多的医疗剂被用于临床和外科伤口。 治愈的场景。重组生长因子在治疗上的应用 治疗顽固性糖尿病和静脉溃疡，同时使用自体生长因子 用于脊柱融合和关节等重要的整形外科应用 植入物。然而，当前增长的成本和/或不便 基于要素的产品阻碍了它们的广泛使用。外科的未来 因此，生长因子治疗剂将取决于自体移植的容易程度 可以获得增长因子，并显著降低成本。 认识到这一点，申请人设计了一种快速、方便的流程 以及相对便宜的术中自体血小板采集 并保留了生长因子。该提案中描述的新系统 消除了对离心机的需要，而且它可以第一次使 从小容量血液中常规采集自体生长因子 在手术期间。通过这一过程采集血小板可以允许 使用各种经批准的底物输送生长因子，例如 水凝胶、胶原蛋白组合物、海藻酸盐等。 概念是使自体生长因子随时可用于 广泛的软硬组织外科应用。 拟议的商业应用：拟议的项目将导致开发一种方便、快速和廉价的方法来分离自体生长因子，以促进各种软组织和硬组织外科手术中的伤口愈合。

DESCRIPTION (provided by applicant): Recombinant and autologous growth factor healants are being utilized increasingly for clinical and surgical wound healing scenarios. Recombinant growth factors are therapeutically applied to heal intractable diabetic and venous ulcers, while autologous growth factors are used in major orthopedic applications such as spinal fusion and joint implants. However, the cost and/or inconvenience of the current growth factor-based products have impeded their widespread use. The future of surgical growth factor healants will thus depend on the ease with which autologous growth factors can be obtained, and significant cost reduction. Recognizing this, the applicants have designed a process for quick, convenient and relatively inexpensive intraoperative harvesting of autologous platelets with preserved growth factors. The novel system described in this proposal obviates the need for centrifugation, and it can, for the first time, enable routine harvesting of autologous growth factors from small volumes of blood during surgery. The harvesting of platelets by this process can allow the delivery of growth factors using a wide variety of approved substrates such as hydrogels, collagen compositions, alginates etc. The eventual goal of this concept is to make autologous growth factors readily available for use in a wide variety of soft and hard tissue surgical applications. PROPOSED COMMERCIAL APPLICATION: The proposed project will lead to the development of a convenient, quick and inexpensive process to isolate autologous growth factors that can be delivered to augment wound healing in various soft and hard tissue surgical procedures.