ALBUMIN GENERATION IN HEMODIALYSIS PATIENTS

本研究的主要目的是比较参与NIH资助的MMHD研究的一组血液透析患者的白蛋白周转率、分布和外部损失。我们将建立基线血浆白蛋白浓度和周转率，营养状况，血浆急性期蛋白水平和血浆白蛋白浓度，为期2年，并在2年结束时或血浆白蛋白浓度变化为4mg /ml或以上时重复测量白蛋白周转率。所有基线白蛋白浓度处于四分位数中最低四分位数的患者，将测量其营养状况、白蛋白和急性期蛋白浓度。另外80%的基线白蛋白值位于前3个四分位数的患者的血清白蛋白浓度将按月测定。

The main objective of this study is to compare the albumin turnover rate, distribution and external loss in a group of hemodialysis patients who are participating in the MMHD study funded by the NIH. We will establish baseline plasma albumin concentration and turnover rate, nutritional status, the levels of acute phase proteins in plasma and plasma albumin concentration for a period of 2 years and repeat measurements of albumin turnover either at the end of the 2 year period or following a change in plasma albumin concentration of 4 mg/ml or more. Measurement of nutritional status and the concentrations of albumin and acute phase proteins will be measured in all patients whose baseline albumin concentration is in the lowest quartile of quartiles. Serum albumin concentration will be determined monthly in the other 80% of patients whose baseline albumin values lie in the upper 3 quartiles in whom albumin turnover is not determined.