EFFECT OF ALPHA MSH ON INFLAMMATION

一些长期透析治疗的患者会出现厌食、消瘦， 高血压、β 2微球蛋白积聚和频繁感染。 这些并发症中的许多被认为是由激活 通过与透析器接触使炎症细胞循环 膜的 被激活的细胞会产生一种叫做前- 炎症细胞因子被认为增加了 肌肉组织和引起全身症状如上所列。这项研究 将检查α-黑素细胞刺激激素对 透析患者的细胞因子产生。 实验室证据 培养的细胞和整个动物表明，α-MSH可以抑制 在许多形式的炎症中产生促炎细胞因子。 我们建议确定α-MSH是否可以预防炎症状态 诱导透析，从而减少短期和长期副作用 方面的影响.

Some patients on long-time dialysis therapy suffer anorexia, wasting, hypertension, beta2 microglobulin accumulation, and frequent infections. Many of these complications are thought to be caused by activation of circulating inflamatory cells through contact with the dialyzer membrane. The activated cells produce substances called pro- inflammatory cytokines which are thought to increase breakdown of muscle tissue and cause systemic symptoms as listed above.This study will examine the action of alpha-Melanocyte Stimulating Hormone on cytokine production in dialysis patients. Laboratory evidence in cultured cells and whole animals indicate that alpha-MSH can inhibit production of pro-inflammatory cytokines in many forms of inflammation. We propose to determine if alpha-MSH can prevent the inflammatory state induced by dialysis and thereby, reduce short-term and long-term side effects.