Multi-scale modelling of blood flow over cardiovascular surfaces

计算建模在生物医学工程领域有许多活跃的研究领域，既具有理论意义，又具有多种相关的临床应用。CFD技术的准确性和能力一直在提高，这使得创建更真实的模型成为可能。这些更复杂的模型可以通过提供对身体功能的洞察来增加我们对人体生理学的理解，研究疾病对身体功能的影响，并通过模拟手术/植入物/医疗设备确定有效的治疗方法。对任何一种血液流动进行建模的一个基本部分是它与边界的相互作用；血管、瓣膜或组织由于这种相互作用对于准确模拟所有类型的血流至关重要，因此对现有技术的任何改进都将改善许多类型的生物医学模拟。我感兴趣的是研究不同尺度血管的不同结构/机械特性对血流的影响，以及改善血液与这些多尺度血管的流变相互作用。由于生物建模中使用了许多CFD方法（有限体积，光滑颗粒流体动力学），因此可以评估不同技术在多尺度流动建模中的适用性。这项研究在临床和商业上都有明确的应用，无论是针对特定患者的模拟，还是为医疗植入物（如导尿管/血栓装置）的设计提供信息。

Computational modelling in the Biomedical Engineering field has many active research areas, with both theoretical significance and multiple relevant clinical applications. The accuracy and capability of CFD techniques is always increasing which allows for the creation of more realistic models. These more sophisticated models can increase our understanding of human physiology by providing insight into the function of the body, investigate the effect disease can have on this function and determine effective treatment through simulating surgery/implants/medical devices. A fundamental part of modelling any kind of blood flow is its interaction with the boundaries, be it; Blood vessels, valves or tissues. As this interaction is critical to modelling accurately all types of blood flow, any improvements that can be made to existing techniques will improve many types of biomedical simulations. I am interesting in examining the effects of the differing structural/mechanical properties of blood vessels at different scales on blood flow, as well as improving the rheological interactions of blood with these multi-scale vessels. As there are many CFD methods used in biological modelling (Finite volume, Smoothed particle hydrodynamics), the performance of different techniques can be assessed for suitability in modelling multi-scale flow. This research has clear clinical and commercial application in both patient-specific simulations and informing the design of medical implants such as catheters/blood clot devices.