Functional Senescence in Drosophila

我的实验室目前由NIMH和其他来源资助，研究果蝇记忆的分子基础，但我之前没有得到过关于衰老研究的外部支持。因此，我是一名进入老龄化研究的老牌调查员。更好地了解功能性衰老的分子基础，将极大地促进旨在改善与年龄相关的功能衰退的治疗。该项目将探索控制果蝇寿命和功能衰老之间的遗传关系。此外，该项目将在果蝇中使用强大的遗传工具来探索功能性衰老的分子基础。总而言之，这些研究将对神经系统功能与年龄相关的变化有很大帮助。

My laboratory is currently funded by NIMH and other sources to study the molecular bases of memory in Drosophila, but I have not previously received extramural support for studies on aging. Thus, I am an established investigator moving into aging research. Therapies aimed at ameliorating age-related functional declines would be greatly facilitated by a better understanding of the molecular bases of functional senescence. This project will explore the genetic relationship between control of longevity and functional senescence in Drosophila. Additionally, this project will use powerful genetic tools in Drosophila to explore the molecular underpinnings of functional senescence. Together, these studies will shed much light on age-related changes in nervous system function.