Clinical Center: Parkinson's Disease Neuroprotection

描述(申请人提供)：这个项目的目标是进行试验性研究，以确定帕金森氏病的假定神经保护剂，并在随机、双盲临床试验中令人信服地证明一种或多种药物减缓帕金森病进展的有效性，并确定这些药剂的毒性和耐受性。我们的临床研究中心将由三个当地站点组成，每个站点都有历史和对进行帕金森病临床试验感兴趣。牵头地点将是托马斯·杰斐逊大学(帕金森疾病研究中心)，在宾夕法尼亚州布林莫尔的主线健康医院和德克萨斯州威尔明顿的神经学协会设有卫星地点。这个联盟横跨费城大都市区、费城人口稠密的西北部郊区、宾夕法尼亚州东南部、新泽西州南部和整个特拉华州，将极大地增强我们在参与的任何研究项目中招募患者的能力。该联盟的优势是参与者的集体研究专业知识，以及由此增加的早期帕金森氏病患者的可获得性。作为这个联盟的结果，我们有信心我们将能够超过招募到研究中的最低患者数量大约50%。这个临床中心的每个组成部分都配备了在帕金森氏病患者的临床和研究评估方面经验丰富的临床人员，以及在招募和保留帕金森氏症患者以及管理临床方案方面经验丰富的护士和临床协调员。

DESCRIPTION (provided by applicant): The objective of this project is to perform pilot studies to identify putative neuroprotective agents for Parkinson's disease and to demonstrate convincingly in a randomized, double-blind clinical trial the efficacy of one or more pharmacological agents for slowing the progression of Parkinson's disease and to determine the toxicity and tolerability of these agents.Our Clinical Research Center will be a consortium of three local sites, each with a history and interest in conducting Parkinson's disease clinical trials. The lead site will be Thomas Jefferson University (Parkinson's Disease Research Unit), with satellite sites at Main Line Health Hospitals in Bryn Mawr, PA and Neurology Associates, P.A. in Wilmington, DE. This consortium, spanning the Philadelphia metropolitan area, the heavily populated northwestern suburbs of Philadelphia, Southeast Pennsylvania, Southern New Jersey and the entire state of Delaware will greatly enhance our ability to enroll patients in any research project in which we participate. The strength of this consortium is the collective research expertise of the participants and the resultant enhanced availability of early Parkinson's disease patients. As a result of this consortium, we are confident that we will be able to exceed the minimum number of patients to be recruited into study by approximately 50%. Each component of this Clinical Center is staffed by clinical personnel experienced in the clinical and research assessment of Parkinson's disease patients and by accomplished nurses and clinical coordinators with experience in the recruitment and retention of Parkinson's disease patients and the administration of clinical protocols.