CENTER ON INTERSYSTEM REGULATION BY DRUGS OF ABUSE

此应用程序是为NIDA P30中心题为“系统间的药物滥用监管。“我们已经发展了一个强大的资助调查小组，致力于药物滥用和成瘾的各个方面。很明显，P30中心将提高跨学科研究的整体生产力，协同作用和整合，并能够招募更多的教师进入滥用和成瘾药物领域。拟议中心的主题是：1）确定滥用和治疗使用的阿片类药物和内源性阿片系统及其配体在调节疼痛，体温，免疫系统和感染（包括艾滋病毒）中的作用; 2）确定负责这些变化的基本机制; 3）比较急性给药药物与慢性给药药物产生的效果。这些主题的必然结果是确定这些系统相对于与滥用药物相关的阿片样物质和内源性系统所涉及的机制的相似性和差异，以及这些系统相对于与滥用药物相关的阿片样物质和内源性系统之间存在的关系，以及这些系统之间存在的关系。鉴于个人很少（如果有的话）只滥用一种药物，确定类阿片与可卡因和大麻等其他滥用药物之间是否发生相互作用尤为重要。将使用体内和体外方法，从行为和活动的整体动物测量到生物化学和分子技术，以评估阿片类药物和其他滥用药物在大脑和外周中的总体作用机制，以及整合这些系统的反馈回路。具有不同专门知识并使用多种方法和技术的许多调查人员之间协同增效的潜力是巨大的。为了实现中心的目标，我们要求6个核心：行政，动物，生化药理学，细胞和免疫学，综合药理学和分子生物学。该中心的成员来自几个部门，并在神经药理学，分子药理学，定量和理论药理学，行为药理学，微生物学（细菌学和病毒学），免疫学和生物化学等领域的专业知识。来自基础科学和临床部门的教师将参与NIDA中心。一个中心将是粘合剂，把其他人吸引到这个范围广泛的杰出科学家群体中来。坦普尔大学医学院已作出重大承诺，提供必要的资金和空间，以形成一个中心。NIDS中心将提供核心设施，以促进目前无法用于个人研究的技术和方法的使用。它将节省成本，提高科学质量和未来研究的愿景。它将真正提供环境，将导致最高质量，创新，国家的最先进的研究。它将为我们的小组提供必要的条件，使其成为药物滥用研究的几个方面的国家资源，特别是药物相互作用和神经免疫药理学。

This application is for a NIDA P30 Center titled "Intersystem Regulation by Drugs of Abuse." We have evolved a strong group of funded investigators working on a variety of aspects of drug abuse and addiction. It has become apparent that a P30 Center would enhance the overall productivity, synergy, and integration of the interdisciplinary research and enable the recruitment of additional faculty into the field of drugs of abuse and addiction. The themes of the proposed Center are: 1) to determine the role of abused and therapeutically used opioids and the endogenous opioid system and its ligands, in regulation of pain, body temperature, the immune system, and infection, including HIV; 2) to determine the basic mechanisms responsible for these changes; 3) to compare effects produced by acutely administered drugs with those of chronically administered drugs. A corollary to these themes will be the determination of the similarities and differences in the mechanisms involved in these systems relative to the opioid and endogenous systems associated with abused drugs, and the relationships that exist among these systems relative to the opioid and endogenous systems associated with abused drugs, and the relationships that exist among these systems. In light of the fact that individuals rarely, if ever, abuse only one drug, it is particularly important to determine whether or not interactions occur between opioids and other abused drugs such as cocaine and marijuana. Both in vivo and in vitro approaches will be used, ranging form whole- animal measurements of behavior and activity, to biochemical and molecular techniques, to assess the overall mechanisms of action of opioids and other drugs of abuse in the brain and the periphery, and the feedback loops that integrate these systems. The potential for synergy among many investigators having diverse expertise and using multiple approaches and techniques is enormous. In order to carry out the aims of the Center, we are requesting 6 Cores: Administrative, Animal, Biochemical Pharmacology, Cell and Immunology, Integrative Pharmacology, and Molecular Biology. Members of the Center come from several departments, and have expertise in such areas as neuropharmacology, molecular pharmacology, quantitative and theoretical pharmacology, behavioral pharmacology, microbiology (bacteriology and virology), immunology, and biochemistry. Faculty from both basic science and clinical departments will be involved in the NIDA Center. A Center will be the glue that holds together and attracts others to this wide-ranging group of outstanding scientists. Temple University School of Medicine has made a major commitment in providing the funds and space necessary to form a Center. The NIDS Center will provide the Core facilities to foster the use of techniques and methods not currently available to the individual research. It will provide cost savings, and raise the quality of the science and the vision of future of research. It will truly provide the environment that will result in the highest quality, innovative, state-of-the-art research. It will provide what is necessary for our group to become a national resource in terms of several aspects of drug abuse research, especially drug interactions and neuroimmunopharmacology.