Central Nervous System Infections in Peru

描述（由申请人提供）：本R21申请建议进一步发展华盛顿大学与秘鲁唯一的神经疾病三级转诊中心神经科学研究所（ICN）之间的研究合作。 这笔赠款的主要目标是开展必要的试点研究，为规划和准备申请资助影响秘鲁人的中枢神经系统感染研究提供信息，重点是：1）艾滋病毒/艾滋病和艾滋病毒合并感染; 2）急性病毒性脑膜脑炎。 目前在秘鲁由华盛顿大学领导的艾滋病毒/艾滋病研究得到了美国国立卫生研究院的支持，并从一个私人基金会，惠康信托基金，并提供了一个神经艾滋病研究计划的发展良好的基础。 特别感兴趣的将是对中枢神经系统与艾滋病有关的合并感染的发病机理、临床流行病学和管理的研究，包括神经囊尾蚴病（一种在秘鲁非常常见并得到充分研究的疾病）和耐多药结核病（影响利马43%的艾滋病毒感染结核病患者）。 秘鲁也为热带脑膜脑炎研究提供了一个很好的机会，它利用了最近建立的由美国海军医学研究中心在秘鲁的分遣队协调的全球新发感染监测系统，该系统为利用对急性脑膜脑炎的哨兵监测提供了独特的机会。 通过与德克萨斯大学加尔维斯顿分校的研究人员合作，这样一个系统可以支持未来对秘鲁的登革热和西尼罗河病毒等热带病毒性脑膜脑炎新问题的临床流行病学研究。 在第一年年初，在我们的外部咨询委员会以及国际公认的共同研究者和秘鲁研究者团队的协助下，我们将举办研究研讨会，以评估ICN与NeuroAIDS和急性脑膜脑炎相关的研究、教育、培训和指导需求和机会;随后不久将制定初步研究议程并启动相关试点研究。 第二年将用于完成和分析这些试点研究，并准备R 01申请。

DESCRIPTION (provided by applicant): This R21 application proposes further development of research collaborations between the University of Washington and the Instituto de Ciencias Neurologicas (ICN), the only tertiary referral center for neurologic disease in Peru. The primary goal of this grant will be to carry out necessary pilot studies to inform the planning and preparation for an application for funding of research on CNS infections affecting Peruvians, emphasizing: 1) HIV/AIDS and HIV co-infection; and 2) acute viral meningoencephalitis. Current UW-led HIV/AIDS research in Peru is supported by NIH, and from a private foundation, the Wellcome Trust, and provides an excellent foundation for development of a NeuroAIDS research program. Of particular interest will be research on the pathogenesis, clinical epidemiology, and management of AIDS-related co-infections of the CNS, including neurocysticercosis a very common and well studied condition in Peru and multidrug-resistant tuberculosis, which affects 43% of HIV-infected individuals with TB in Lima. Peru also provides a good opportunity for research on tropical meningoencephalitis, capitalizing on a recently established Global Emerging Infections Surveillance (GELS) system coordinated by the U.S. Navy Medical Research Center Detachment (NMRCD) in Peru, which provides the unique opportunity to leverage addition of sentinel surveillance for acute meningoencephalitis. In collaboration with investigators at the University of Texas-Galveston, such a system could support future research on clinical epidemiology of emerging problems in tropical viral meningoencephalitis, such as dengue and West Nile viruses, in Peru. At the beginning of the initial year, with the assistance of our External Advisory Committee, and a team of internationally-recognized co-investigators and Peruvian investigators, we will conduct research workshops to assess research, education, training, and mentoring needs and opportunities related to NeuroAIDS and acute meningoencephalitis at the ICN; followed soon by development of a preliminary research agenda and initiation of relevant pilot studies. The second year will be used to complete and analyze these pilot studies and prepare the R01 application.