Epigenetic regulation of male fetal germ cell development.

近几十年来，男性的健康状况有所下降，但其原因尚不清楚。影响男性生殖细胞(产生精子)的形成和功能的非遗传(表观遗传)机制可能起着重要作用。我们将确定一种关键的表观遗传修饰物在包括生殖细胞肿瘤在内的雄性生殖细胞的形成和功能中的作用。这项研究将提供对男性生殖细胞表观遗传学的基本见解，并对了解男性的健康做出重大贡献。

Men’s health has declined over recent decades, but the causes remain unknown. Non-genetic (epigenetic) mechanisms affecting formation and function of the male germ cells (which produce sperm) may play an important role. We will determine the role of a key epigenetic modifier on the formation and function of male germ cells, including germ cell tumours. This study will provide fundamental insights into male germ cell epigenetics, and significantly contribute to understanding men's health.