ALTERATION, EQUIPMENT AND RENOVATION SUPPLEMENT

描述(由申请者提供)：华盛顿大学心血管生物医学研究卓越中心(COBRE)汇集了具有不同专业知识的教职员工。心血管COBRE的科学主题源于对导致心血管疾病的应激源的细胞反应的共同兴趣。此外，该项目继续加强威斯康星州大学的生物医学研究网络，并通过与威斯康星州大学生物医学研究基础设施网络(BRIN)的合作伙伴关系。拟议的改进建立在最初的Cobre申请中提出的短期和长期目标的基础上。此外，最初为协助Cobre调查人员而开发的共焦显微镜基础设施使校园内的所有生物医学研究人员受益，包括第二届UW Cobre的成员，即一氧化氮生物学。通过购买BioRad激光扫描(使用蓝光二极管激光)共焦显微镜，该应用程序继续在此基础设施上构建，该显微镜具有对传统荧光染料和近紫外线荧光染料成像的能力，从而满足了Cobre研究人员和校园内其他生物医学研究人员的需求。威斯康星州政府提供了大约3,000平方英尺。英国《金融时报》用作核心显微镜设备的实验室区域。新的显微镜设备需要翻新，以使其最适合容纳共焦和透射式电子显微镜，并为新聘用的显微镜设备主任提供办公室(由两个UW Cobre奖支持)。科布雷将招聘教师列为优先事项，目前正在寻找两名新员工，一名在心血管药理学领域，另一名在心血管神经科学领域。新招聘的人员预计将成为心血管科布雷的一部分，并将作为初级教员接受指导。研究空间是可用的，但需要重新装修。改建是任何实验室的基础，包括安装柜台和橱柜，以及安装足够的电线。总体而言，这项奖励补充继续沿着最初Cobre申请中确定的道路进行，并通过购买最先进的设备和翻新Cobre研究员研究实验室来建立生物医学研究基础设施。

DESCRIPTION (provided by applicant): The Cardiovascular Centers of Biomedical Research Excellence (COBRE) at the UW brings together faculty with diverse expertise. The scientific theme of Cardiovascular COBRE stems from a common interest in the cellular responses to stressors that result in cardiovascular disease. In addition, the project continues to strengthen a biomedical research network at UW and through its partnership with the UW Biomedical Research Infrastructure Network (BRIN). The proposed improvements build on the short- and long-term goals that were proposed in the original COBRE application. In addition, Confocal Microscopy infrastructure that was initially developed to assist COBRE investigators has benefited all the biomedical researchers on campus, including members of the second UW COBRE, The Biology of Nitric Oxide. This application continues to build on this infrastructure through the purchase of a BioRad laser scanning (with Blue Diode laser) confocal microscope that has the capability of imaging traditional flurochromes and near ultraviolet flurochromes, and thereby meets the needs of COBRE researchers and other biomedical research faculty on campus. The UW administration has provided approximately 3,000 sq. ft. laboratory area for use as a core Microscopy Facility. The new Microscopy Facility requires renovations to make it optimally suited to house the confocal and transmission electron microscope and provides an office for the newly hired Director of the Microscopy Facility (supported through the two UW COBRE awards). Faculty recruitment was set as a priority in the COBRE and are seeking two new hires, one in the area of cardiovascular pharmacology and the other in cardiovascular neuroscience. The new hires will be expected to be part of the Cardiovascular COBRE and will be mentored as a junior faculty. Research space is available but it requires remodeling. The remodeling is basic to any laboratory and includes the installation of counters and cabinets and the installation of adequate electrical wiring. Collectively, the award supplement continues in the path identified in the original COBRE application and builds the biomedical research infrastructure through the purchase of state of the art equipment and the renovation of COBRE investigator research laboratories.