TETANUS TOXIN MONOLAYER CRYSTAL

我们已经再次努力进行结构分析， 与其一起生长在磷脂上的破伤风毒素 天然神经节苷脂配体。我们之前的分析表明 获得10以上高分辨率图像数据的可能性使用 泛光灯照明。我们计划改变结晶 获得更有序的二维晶体的条件和使用 斑点扫描成像，以获得更好的图像。我们觉得这个项目 有潜力成为高等职业教育发展的核心项目 用分辨率二维晶体结构分析代替 已终止的巴豆腐毒素复合体晶芯项目。这个 这个项目的意义部分在于解决了一种未知的蛋白质 结构，并在一定程度上显示确定高 生长的蛋白质晶体的分辨率三维结构 磷脂单分子膜。

We have renewed our effort to pursue the structural analysis of the tetanus toxin which was grown on the phospholipid along with its natural ganglioside ligand. Our previous analysis suggested the possibility of obtaining high resolution image data beyond 10
using flood beam illumination. We plan to vary the crystallization condition to obtain more ordered two-dimensional crystals and to use spot-scan imaging to obtain better images. We feel that this project has a potential to become a core project for the development of high resolution two-dimensional crystal structure analysis in place of the crotoxin complex crystal core project which has been terminated. The significance of this project is partly to solve an unknown protein structure and partly to show the feasibility of determining the high resolution three-dimensional structure of protein crystals grown on phospholipid monolayers.