Visceral Fat and Autonomic-Circulatory Control in Humans

描述(由申请人提供) 此K02奖项提案要求提供薪资支持，以保护申请者的时间 专注于拟议的学习和相关的职业发展计划。这个 首席调查员的长期职业目标是制定一项全国性的 公认的，由外部资助的实验室，专注于确定 肥胖患者自主神经循环功能障碍的机制和后果， 尤其是那些腹部内脏脂肪升高的人。为此， 本提案的目的是确定高架飞机的影响 腹部内脏脂肪对：1)心脏迷走神经调节心率和 人体肌肉交感神经活动(MSNA)；2)动脉压力感受性反射 刺激心脏迷走神经流出和抑制MSNA，以及3)血管 人类对交感神经刺激的反应性。申请人亦须 建议获得有关DNA序列影响的初步数据 特定候选基因的单独变异和与升高的结合 腹部内脏脂肪对自主循环表型的影响。这项研究 在这个K02奖中提出的将允许候选人扩大他的范围 目前的R01奖，并增强了他在多个领域的研究技能 与人类的肥胖和自主循环控制有关，即1) 拓展神经生理学和血管成像的用途和应用 技术；2)获得身体评估方面的额外培训 身体脂肪的组成和区域分布；3)获得经验 以及研究DNA序列影响的生理基因组学技巧 自主神经循环表型特定候选基因的变异 单独和合并腹部内脏脂肪升高。受保护的人 该奖项提供的时间和研究技能的增强将使 未来很好地进行生物医学研究的候选人。结果是 这项研究将提供新的生理和临床上的重要意义。 关于内脏脂肪和遗传因素的单独贡献的信息以及 结合人类自主循环控制的变异。这 考虑到越来越多的人认识到自主神经 功能障碍可能是许多CVD状态的原因因素(例如，必需的 高血压)，所有这些都变得更加普遍，随着 全身和腹部内脏脂肪，特别是易感人群 个人。(摘要结束)

DESCRIPTION (provided by applicant) This K02 Award proposal requests salary support to protect the applicants time to focus on the proposed studies and associated career development plan. The principal investigator's long-term career goal is to develop a nationally recognized, extramurally funded laboratory focused on determining the mechanisms and consequences of autonomic-circulatory dysfunction in obesity, particularly in those with elevated abdominal visceral fat. Toward this end, the aims of the present proposal are to determine the influence of elevated abdominal visceral fat on: 1) cardiac vagal modulation of heart rate and muscle sympathetic nerve activity (MSNA) in humans; 2) arterial baroreflex stimulation cardiac vagal outflow and inhibition of MSNA, and 3) vascular responsiveness to sympathetic stimulation in humans. The applicant also proposes to obtain preliminary data regarding the influence of DNA sequence variations in specific candidate genes alone and in combination with elevated abdominal visceral fat on autonomic-circulatory phenotypes. The research proposed in this K02 Award will allow the candidate to expand the scope of his current R01 award and enhance his research skills in a number -of areas related to obesity and autonomic-circulatory control in humans namely, 1) to expand the use and application of neurophysiological and vascular imaging techniques; 2) to obtain additional training in the assessment of body composition and regional body fat distribution; and 3) to obtain experience and skills in physiological genomics to study the influence of DNA sequence variations in specific candidate genes on autonomic-circulatory phenotypes alone and in combination with elevated abdominal visceral fat. The protected time and enhancement of research skills provided by this award will equip the candidate to conduct biomedical research well into the future. The results of this investigation will provide new physiologically and clinically important information regarding the contribution of visceral fat and genetics alone and in combination to human variation in autonomic-circulatory control. This information is crucial considering the growing recognition that autonomic dysfunction may be causal factor in a number of CVD states (e.g., essential hypertension) all of which become more prevalent with increasing levels of total body and abdominal visceral fat, particularly in susceptible individuals. (End of Abstract)