Pediatric AIDS Clinical Trials Group

描述（由申请人提供）：继续儿科艾滋病 圣裘德儿童研究医院临床试验部门及其子中心 在田纳西大学和范德比尔特大学提出。新 与圣路易斯华盛顿大学和Meharry Medical有联系 学院为目前的项目提出。目标是支持 协调和研究行动中心（CORC）的科学议程 由Spector博士等人提出，以及NIAID艾滋病毒/艾滋病研究议程。的 三个主办城市，孟菲斯和纳什维尔，田纳西州和圣路易斯，密苏里州位于 美国中部，在非裔美国人密度高的城市地区 人口。这一少数群体的新感染病例有所增加， 尤其是在青少年中。所有人都为周围的人提供艾滋病毒特异性护理， 农村人口也是。这三个项目中的每一个都具有重要意义。 艾滋病毒感染婴儿、儿童、青少年的管理经验， 和孕妇。与Ryan白色的联系，每个城市的标题四计划 增加患者参与临床试验的机会。建议PACTG的团队 研究中心包括儿科和成人领域的知名学术专家， 传染病，免疫学，药理学，病毒学，胎儿和母体 医学和疫苗学。调查小组在以下方面经验丰富： 设计和开展多中心临床试验，并已成功 自1992年以来参加PACTG，一直被评为优秀。 来自该网站的调查人员为推进科学目标做出了贡献 并担任过重要领导职务。范德比尔特和 华盛顿大学是成人ACTU的所在地， 与这些单位合作，为青少年和孕妇提供服务。 范德比尔特大学也是艾滋病毒疫苗试验单位的所在地。 在今后五年中，我们将继续推进科学议程， 通过招募婴儿、儿童青少年和 PACTG协议中的孕妇，参与新的 临床试验和PACTG的领导，并提供与 合作网络，如青少年审判网络，以及基本的 科学家在我们的机构。

DESCRIPTION (provided by applicant): Continuation of the Pediatric AIDS Clinical Trials Unit at St. Jude Children's Research Hospital and its subsites at the University of Tennessee and Vanderbilt University is proposed. New affiliations with Washington University in St. Louis and Meharry Medical College are proposed for the current project. The objective is to support the scientific agenda of the Coordinating and Research Operations Center (CORC) proposed by Dr. Spector et al. and the NIAID HIV/AIDS research agenda. The three host cities, Memphis and Nashville, TN and St. Louis, MO are located in Mid-America, within urban areas with high-density African-American populations. There has been an increase in new infections in this minority, especially among adolescents. All provide HIV - specific care for surrounding rural populations as well. Each of the three programs has significant experience in the management of HIV-infected infants, children, adolescents, and pregnant women. Linkages with Ryan White, Title IV programs in each city enhance the access of patients to clinical trials. The team of proposed PACTG sites includes well-established academic specialists in pediatric and adult infectious diseases, immunology, pharmacology, virology, fetal and maternal medicine, and vaccinology. The team of investigators is experienced in the design and conduct of multicenter clinical trials and has successfully participated in the PACTG since 1992, consistently ranked as excellent. Investigators from this site have contributed to advancing the scientific aims of the group and have served in key leadership positions. Vanderbilt and Washington Universities are sites of Adult ACTUs and provide the opportunity to collaborate with these units for aging-up adolescents and pregnant women. Vanderbilt University is the also the site of an HIV Vaccine Trials Unit. During the next five years we will continue to advance the scientific agenda of the PACTG through the enrollment of infants, children adolescents and pregnant women in PACTG protocols, participate in the development of new clinical trials and leadership of the PACTG, and provide linkages with collaboration networks, such as the Adolescent Trials Network, and basic scientists at our institutions.