HUC BIOMEDICAL RESEARCH IMPROVEMENT PROGRAM

HUC生物医学研究改进计划是与 为教职员工提供手段的目的是 胡马考大学学院将进入生物医学的主流 研究。同时，学生参与者也参与了 刺激和更好地获得生物医学资格的研究项目 研究生。 这项延续申请涉及五个子项目；其中四个是 化学系的，物理系的。一 子项目将确定控制的热力学参数 半喹酮类化合物与模型生物系统相互作用的稳定性 并将确定氧气和一氧化氮的形成速度 在氧化还原和超声波系统中与环境/半喹酮有关 物理性质，目的是了解其细胞毒活性 含有抗肿瘤药物的苯二酚。另一个子项目设计新 对映体选择性合成方法研究进展 具有生物活性的化合物，可避免产生 在药学中具有潜在毒性的外消旋混合物 由于有毒对映体的存在而导致的产品。《第三化学》 子项目的目的是改善由 有机溶剂中的酶催化不对称转化 导致了与生物医学相关的化合物。另一个化学子项目 将测量选定基团的分子/光物理性质 三环类抗神经药，目的是了解过敏性 在使用这些药物的患者中，光敏反应会出现副作用 毒品。物理子项目将研究加热和成像非 在强磁场下对大脑进行成像的一致性问题 计算机模型，以了解采暖和差的影响 当使用高场强时，可以获得高质量的图像。 本科生将参与这些子项目。他们是 在不同的实验室接受培训，光谱和计算 应用于生物医学研究的技术。预计将会有 该项目的开发将作为一种手段，以获得所需的 目标，即教师获得生物医学主流研究支持 以及毕业于医学或牙科研究生的学生 学校和从事生物医学研究的职业。

The HUC Biomedical Research Improvement Program has been created with the purpose of providing the means by which faculty members at the Humacao University College will enter into the main stream of biomedical research. At the same time, student participants are involved in research projects which stimulate and better qualify for biomedical graduate students. This application for continuation involves five subprojects; four are from the Chemistry area, and one from the Physics department. One subproject will determine the thermodynamic parameters controlling the stability of the semiquinones interacting with model biological systems and will determine how the rates of formation of oxygen and nitric oxide in redox and ultrasound systems relates to environmental/semiquinone physical properties with the aim of understanding the cytotoxic activity of antitumor quinone containing drugs. Another subproject design new methodologies for the enantioselective synthesis for enantiopure compounds with biological activity which will avoid the production of racemic mixtures which have potential toxic effects in pharmaceutic products due to the presence of the toxic enantiomer. A third Chemistry subproject is aimed at improving the synthetic scope afforded by enzymatic catalysis in organic solvents for asymmetric transformation leading to biomedical relevant compounds. Another Chemistry subproject will measure the molecular/photophysical properties of a selected group of tricyclic neuroleptics with the aim of understanding the allergical and photosensitization occurring as side effects in patients using these drugs. The physics subproject will study the heating and image non- uniformity problems in imaging the brain at high magnetic fields using computer models in order to understand the effects of heating and poor image quality and obtained when high field strengths are used. Undergraduate students will participate in these subprojects. They are trained in different laboratories, spectroscopic and computation techniques as applied to biomedical research. It is expected that the development of this project will serve as a means to obtain the desired goals, i.e., faculty obtaining biomedical mainstream research support and students entering, graduating from graduate, medical or odontology schools and following a biomedical research career.