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Role of the IgE-FceRI network in allergic inflammation

Role of the IgE-FceRI network in allergic inflammation
IgE-FceRI 网络在过敏性炎症中的作用
批准号：
6609699
负责人：
JEAN-PIERRE M KINET
金额：
$38.25万
依托单位：
BETH ISRAEL DEACONESS MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2001
资助国家：
美国
项目状态：
已结题
起止时间：
2001-09-30 至 2006-05-31
来源：
https://reporter.nih.gov/project-details/6609699
关键词：
anaphylaxis animal breeding antibody receptor antigen presentation asthma eosinophil genetically modified animals hypersensitivity immunoglobulin E laboratory mouse macrophage monocyte passive immunization receptor expression

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中文摘要
翻译
本提案概述了一个旨在满足哮喘和过敏性疾病研究（AADRC）要求的项目。IgE-FceRi网络在过敏性炎症中的作用。所有这些都被一个中心主题所统一，即导致哮喘疾病发展的三个主要步骤：针对过敏原的初始免疫阶段（步骤1），Th2反应的扩增（步骤2），以及效应反应和哮喘的发展（步骤3）。本项目假设以alphagamma2形式表达高亲和力IgE受体的细胞参与IgE免疫应答的调控（步骤2），并参与体内IgE- FcepsilonRI网络的效应功能（步骤3）。
英文摘要
This proposal outlines a project designed to meet the requirements for an Asthma and Allergic Diseases Research (AADRC). Role of the IgE-FceRi network in allergic inflammation. All are united by the central theme that three major steps lead to the development of the asthmatic disease: the initial immunization phase against allergens (step 1) the amplification of the Th2 response (step 2), and the development of the effector response and asthma (step3). The hypothesis of this project is that cells expressing high affinity IgE receptor in the form of alphagamma2 contributes to the regulation of the IgE immune response (step 2) and participates in the effector functions of the IgE- FcepsilonRI network in vivo (step 3).
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