A Spiking Model of Hippocampus for Guiding Behavior

描述（由申请人提供）：拟议的研究重点是开发一个详细和现实的模型，说明海马体、内嗅皮层、前额叶皮层和腹侧被盖区的神经放电模式如何在特定的行为任务中介导目标导向行为。这些项目探讨了目标激活，反应选择和情景记忆的相互作用，以指导行为。理解这些动机行为的过程对于理解药物成瘾过程是很重要的。特别是这项工作允许建模如何在许多相互作用的区域内的多巴胺能，γ-氨基丁酸能胆碱能和多巴胺能过程的改变可能会影响成瘾行为。拟议的研究将进一步开发现有的软件，允许神经模拟和虚拟环境中虚拟大鼠的行为之间的直接接口，该模型同时受到行为功能和生物现实结构要求的约束。神经模拟使用基于关于节律场电位（EEG）和单个神经元的放电模式（单元记录）的广泛生理数据的动力学。这里提出的研究将涉及三个群体之间的持续互动： 1.爱丁堡的研究小组（Robert Cannon和奈杰尔戈达德）将提供一个灵活的、基于图形的模拟包（CATACOMB）的持续开发，该模拟包允许构建神经模拟，用于指导虚拟大鼠在各种不同实验任务中的行为，包括空间记忆任务和操作任务。 2.哈塞尔莫小组将继续开发海马体、内嗅皮层、前额叶皮层和腹侧被盖区如何参与行为任务中目标导向运动的模拟。这项工作将产生明确的实验预测尖峰的时间相对o的行为和相对θ节律EEG的基础上的生理相互作用的假设。 3. Eichenbaum小组将分析来自空间交替任务的数据，以测试模拟对行为期间尖峰时间的具体预测。 该项目将与B.U.的Hasselmo和Kantak实验室之间的单独合作产生协同作用，该项目的重点是对药物自我给药现象实验研究中使用的操作性任务进行建模，这项工作得到了NIDA先前资助的补充。

DESCRIPTION (provided by applicant): The proposed research focuses on development of a detailed and realistic model of how neural firing patterns in the hippocampus, entorhinal cortex, prefrontal cortex and ventral tegmental area mediate goal directed behavior in specific behavioral tasks. These projects explore the interaction of goal activation, response selection and episodic memory for guiding behavior. Understanding these processes of motivated behavior should prove important for understanding the drug addiction processes. In particular this work allows modeling of how alterations in glutamatergic, GABAergic cholinergic and dopaminergic processes within numerous interacting regions could influence addictive behavior. The proposed research will further develop existing software that allows a direct interface between a neural simulation and behavior of a virtual rat in a virtual environment, a model simultaneously constrained by requirements about behavioral function and biologically realistic structure. The neural simulation uses dynamics based on extensive physiological data on rhythmic field potentials (EEG) and firing patterns of individual neurons (unit recording). The research proposed here will involve a continuous interaction between three groups: 1. The group in Edinburgh (Robert Cannon and Nigel Goddard) will provide ongoing development of a flexible, graphics based simulation package (CATACOMB), which allows construction of neural simulations for guiding behavior of a virtual rat in a variety of different experimental tasks, including spatial memory tasks and operant tasks. 2. The Hasselmo group will continue development of simulations of how the hippocampus, entorhinal cortex, prefrontal cortex and ventral tegmental area are involved in goal directed movements in behavioral tasks. This work will generate clear experimental predictions about the timing of spikes relative o behavior and relative to theta rhythm EEG based on hypotheses about the physiological interaction. 3. The Eichenbaum group will analyze data from a spatial alternation task to test specific predictions of the simulation about the timing of spikes during behavior. This project will have a synergistic interaction with a separate collaboration between the Hasselmo and Kantak laboratories at B.U., which focuses on modeling operant tasks used in experimental studies of drug self-administration phenomena, in work supported by a supplement to a previous grant from NIDA.