Obesity and cardiac Risk in American Indian Children

描述(由申请人提供)： 背景：儿童肥胖是成人肥胖发展的重要危险因素， 心血管疾病(CVD)和糖尿病。最近的研究表明，美国印第安人(AI)儿童的肥胖率非常高。候选人：这个K23奖项将促进亚历山德拉·亚当斯博士的 作为一名以患者为中心的科学家，以成为一名高质量、 独立的学术研究人员，制定预防艾滋病的干预策略 Al人群中的肥胖、心血管疾病和糖尿病。资格：亚当斯博士独特的资格 这项K23奖项包括她的医学培训和营养学博士学位。自从加入了 作为威斯康星大学(UW)家庭医学(DFM)临床和研究教授，她在1999年与威斯康星州的Al社区建立了牢固的工作关系，并与部落社区启动了许多重要的合作研究。环境：DFM和 医学院致力于将亚当斯博士培养成一名以患者为中心的科学家。这是 反映在强烈的支持信中，参与该项目的高级研究导师写道 她的主席的承诺、GCRC的支持以及与其他UW的合作机会 在美国最强大的研究环境之一的研究团队。培训：亚当斯博士将通过获得临床高级培训，在以患者为中心的研究领域发展她的职业生涯 研究设计、总体统计、参与性研究、伦理、写作技能和高级机构 作曲技巧。作为她K-23计划的一部分，她将完成华盛顿大学的临床调查员 准备课程(CIPP K30补助金)以及参加课程、研讨会和培训 活动。她将接受来自LTW的广泛的小组和一对一的指导 美国国立卫生研究院资助的资深科学家和卡纳瓦克学校主任安·麦考利博士 麦吉尔大学的糖尿病预防计划。研究：亚当斯博士正在研究一种3 阶段性协作参与式研究项目，与两个具有 要求她与他们合作，通过以下方式减少他们社区的疾病负担 减少孩子肥胖和心血管疾病的危险因素。她假设最高的 智力低下儿童的肥胖率，这使他们处于成人心血管疾病和 糖尿病，在童年早期就开始了。因此，肥胖预防工作必须在早期就有针对性。 童年。该项目将1)评估Al儿童的肥胖率和心脏危险因素 年龄0-7岁，2)对儿童的家庭和环境决定因素进行生长模拟 肥胖，以及3)与社区合作，设计基于社区的早期 预防儿童肥胖的干预策略。意义：在K23的帮助下 获奖后，亚当斯博士将开发和测试干预措施，以预防Al儿童及其 后遗症；心血管疾病和糖尿病。

DESCRIPTION (provided by applicant): Background: Childhood obesity is a significant risk factor for the development of adult obesity, cardiovascular disease (CVD), and diabetes. Recent studies suggest very high rates of obesity in American Indian (AI) children. Candidate: This K23 award will facilitate Dr. Alexandra Adams' development as a patient-oriented scientist with a long-term goal of becoming a high-quality, independent academic investigator who develops intervention strategies for prevention of obesity, CVD and diabetes in Al populations. Qualifications: Dr. Adams' unique qualifications for this K23 award include her medical training and a Ph.D. in nutritional science. Since joining the University of Wisconsin (UW) Family Medicine (DFM) clinical and research faculty in 1999, she has established a strong working relationship with Al communities in Wisconsin and has initiated a number of important collaborative studies with tribal communities. Environment: The DFM and Medical School are committed to Dr Adams' development as a patient-oriented scientist. This is reflected in strong support letters, senior research mentors involved with the project, written commitment from her Chair, GCRC support, and collaborative opportunities with other UW research teams in one of the strongest research environments in the US. Training: Dr. Adams will develop her career in patient-oriented research by obtaining advanced training in clinical research design, blostatistics, participatory research, ethics, writing skills, and advanced body composition techniques. As part of her K-23 plan, She will complete the UW Clinical Investigator Preparatory Pathway (CIPP K30 grant) as well as participate in courses, seminars and training activities. She will receive extensive group and one-on-one mentoring from a number of LTW senior NIH-funded scientists and Dr. Ann Macaulay, Director of the Kahnawake Schools Diabetes Prevention Program at McGill University. Research: Dr Adams is working on a three phase collaborative participatory research project with two WI tribal communities who have asked her to partner with them to reduce the disease burden in their communities by decreasing obesity and CVD risk factors in their children. She hypothesizes that the high prevalence of obesity in WI Al children, which places them at high risk for adult CVD and diabetes, begins early in childhood. Thus, obesity prevention efforts must be targeted early in childhood. The project will 1) assess obesity prevalence and cardiac risk factors in Al children ages 0-7, 2) conduct growth modeling of the familial and environmental determinants of obesity, and 3) work in partnership with the communities to design community-based early intervention strategies to prevent childhood obesity. Significance: With the assistance of the K23 award, Dr. Adams will develop and test interventions to prevent obesity in Al children and its sequelae; CVD and diabetes.