Immunopathology Training Grant

描述(由申请人提供)：此申请是为了支持加州大学洛杉矶分校细胞和分子病理学研究生项目的博士前研究员的培训，他们对免疫病理学和炎症领域的研究感兴趣。细胞和分子病理学项目是加州大学洛杉矶分校病理学和实验室医学系的博士学位授予单位。该计划的一个显著特点是，学生接受的培训是在免疫学和病理学领域之间架起一座桥梁。后一个目标是通过参加特别研讨会和病理学大轮演讲，与细胞和分子病理学培训计划教员(其中许多人是执业病理学家)的互动以及教学课程计划来实现的。所有学生完成细胞生物学和分子遗传学的课程，以及一门核心的病理学课程，其中包括炎症和修复等基本病理概念的指导，以及旨在了解疾病机制的讲座。此外，免疫病理学实习生将被要求完成高级免疫学课程和额外的免疫病理学研究课程。因此，在预期的五年培训过程中，受训者将学会将细胞水平的发现与系统过程相结合，并获得将临床领域中定义的问题翻译和回答到实验室工作台上的专业知识，反之亦然。超过一半的研究生项目教员，以及目前注册参加细胞和分子病理学项目的34名博士前研究员中的17名，从事免疫病理学/炎症领域的研究。该项目的大多数学生通过UCLA Access进入加州大学洛杉矶分校，这是一个由11个系联合管理的招生过程和一年级课程，然后转到细胞和分子病理学项目。额外的受训人员是医学博士/博士候选人，以及正在攻读博士学位的实习医学博士。正在研究的具体研究课题包括淋巴细胞发育，趋化因子和抗菌肽在宿主防御和炎症中的作用，免疫系统细胞在促进炎症过程中的作用，移植生物学，微生物发病机制，以及调节单核细胞激活的核受体。这项研究是在病理学和实验室医学部进行的。

DESCRIPTION (provided by applicant): This application is being submitted to support the training of pre-doctoral fellows, enrolled in the Cellular and Molecular Pathology Graduate Program at UCLA, with research interests in the area of Immunopathology and Inflammation. The Cellular and Molecular Pathology Program is the Ph D granting unit of the Department of Pathology and Laboratory Medicine at UCLA. A distinguishing feature of this program is that students are trained to bridge the gap between the fields of immunology and pathology. This latter goal is accomplished through attendance at special seminars and Pathology Grand Rounds presentations, interactions with Cellular and Molecular Pathology training program faculty, many of whom are practicing pathologists, and a program of didactic coursework. All students complete courses in cell biology and molecular genetics and a core Pathology course in which instruction in basic pathologic concepts, such as inflammation and repair, and lectures designed to understand mechanisms of disease are presented. In addition, immunopathology trainees will be required to complete an advanced immunology course and additional research courses in immunopathology. As a result, over the course of their anticipated five years of training, trainees will learn to integrate findings at the cellular level with systemic processes and obtain the expertise to translate and answer questions defined in the clinical area to the laboratory bench and vice-versa. Over half of the graduate program faculty, as well as 17 of the 34 pre-doctoral fellows currently enrolled in the Cellular and Molecular Pathology program, conduct research in the area of immunopathology/inflammation. Most students in the program entered UCLA via UCLA ACCESS, an admissions process and first year curriculum jointly administered by 11 departments, prior to transfer into the Cellular and Molecular Pathology program. Additional trainees are M D/Ph D candidates as well as practicing M D's who are undertaking Ph D studies. Specific research topics being studied include lymphocyte development, actions of chemokines and anti-microbial peptides in host defense and inflammation, the role of immune system cells in promoting inflammatory processes, transplantation biology, microbial pathogenesis, and nuclear receptors that regulate monocyte activation. This research is conducted in the Department of Pathology and Laboratory Medicine.