INSTITUTIONAL PRE-DOCTORAL NRSA

癌症是一系列疾病，其控制最终需要对允许细胞以不受控制的方式开始分裂并随后侵入正常组织的事件有基本的了解。细菌和真菌机会性感染已成为免疫功能低下患者发病和死亡的主要原因，特别是那些接受高剂量化疗治疗实体瘤，或长期治疗白血病、淋巴瘤和其他癌症相关血液病的患者。该培训计划的目标是指导博士生在多学科的肿瘤发生和发病机制方面进行基础研究。主要目标是培养年轻的科学家，他们将继续他们在癌症生物学和宿主-病原体相互作用方面的职业生涯，并随后在他们感兴趣的特定研究领域产生影响。参与该项目的教师代表了医学院最具竞争力的科学家，他们对癌症的发生和发病机制感兴趣，他们来自病理科、生物化学和分子生物学、生理学和分子医学、医学、微生物学和免疫学。教师参与者包括博士。M. You（肺癌分子遗传学），J.C. Willey（肺癌致癌物），R. Ruch（细胞-细胞通讯），J.P. Trempe（癌症基因治疗），M. Ratnam（癌症新化疗方法），L. Faber（黄体酮、免疫抑制剂和乳腺癌），M. Pereira（结直肠癌预防），D.L. Sawicki（病毒复制调节），M. Boyle（纤溶酶原激活和细菌发病机制）。G.T. Cole（与机会性真菌侵袭相关的免疫调节）和D.W. Metzgar（免疫细胞因子调节）。所有博士预科学生都将通过现有的俄亥俄医学院医学科学项目进入疾病分子基础或分子和细胞生物学领域的课程集中。除了课程集中的要求外，这个名为“癌症分子发病机制”（Molecular mechanism of Cancer， MPC）的培训项目的学生将被要求学习2门与癌症相关的课程，并参加培训项目活动（系列研讨会、期刊俱乐部、研究会议和研究静修）。

Cancer is a spectrum of diseases whose control will ultimately require a basic understanding of the events that permit cells to begin to divide in an uncontrolled manner and subsequently invade normal tissue. Bacterial and fungal opportunistic infections have emerged as major causes of morbidity and mortality in immunocompromised patients, particularly those undergoing high dose chemotherapy for the treatment of solid tumors, or prolonged treatment for leukemia, lymphoma and other cancer-related hematologic disorders. The objectives of the proposed training program will be to direct predoctoral students in basic research on multi-disciplinary aspects of carcinogenesis and pathogenesis. The major goal is to train young scientists who will continue their careers in cancer biology and host-pathogen interactions, and subsequently make an impact on their specific area of research interest. The faculty participants in this program represent the medical school's most competitive scientists with interest in carcinogenesis and pathogenesis, and are drawn from the Departments of Pathology, Biochemistry and Molecular Biology, Physiology and Molecular Medicine, Medicine, and Microbiology and Immunology. The faculty participants include Drs. M. You (molecular genetics of lung cancer), J.C. Willey (carcinogens implicated in lung cancer), R. Ruch (cell-cell communication), J.P. Trempe (gene therapy of cancer), M. Ratnam (novel chemotherapeutic approaches to cancer), L. Faber (progestins, immunosuppressants and breast cancer), M. Pereira (prevention of colorectal carcinoma), D.L. Sawicki (regulation of viral replication), M. Boyle (plasminogen activation and bacterial pathogenesis. G.T. Cole (immunomodulation related to opportunistic fungal invasion), and D.W. Metzgar (cytokine regulation of immunity). All predoctoral students will matriculate through the existing Medical College of Ohio's Medical Sciences Program in either the Molecular Basis of Disease or Molecular and Cellular Biology areas of programmatic concentration. In addition to the requirements of the programmatic concentration, students in this training program, called Molecular Pathogenesis of Cancer (MPC) will be required to take 2 cancer-oriented courses and participate in training program activities (seminar series, journal club, research conferences and research retreats).