Doctoral Dissertation Research: The Zoonotic Origins of Tuberculosis Infection in the Pre-contact Americas

博士论文研究:接触前美洲结核病感染的人畜共患起源

基本信息

  • 批准号:
    1945812
  • 负责人:
  • 金额:
    $ 3.14万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-04-01 至 2021-08-31
  • 项目状态:
    已结题

项目摘要

Mycobacterium tuberculosis has a global distribution and infects over a million new people each year. In the pre-contact Americas, tuberculosis (TB) infection was caused by a strain that is found today in seals and sea lions. This doctoral dissertation project investigates how a zoonotic strain of TB adapted to humans as a primary host and spread across the Americas. Throughout the project, undergraduate students at Arizona State University will be trained in genomic lab work and analysis, and the resulting datasets will be used to create undergraduate-level workshops. The research team will demonstrate an equitable international collaboration by fostering mutual understanding and inclusivity among affiliated parties, thereby facilitating long-term, innovative, and productive relationships between institutions.The Mycobacterium tuberculosis complex (MTBC) refers to a group of similar pathogens that cause TB infection in humans and animals. Genomes extracted from archaeological remains show that zoonotic lineages were responsible for human TB infections in the past. Most TB infections in humans today, however, are caused by M. tuberculosis, the human-adapted MTBC lineage. The evolutionary steps of an animal-adapted pathogen becoming a human-adapted pathogen are not entirely understood. The researchers will draw comparisons between modern and ancient MTBC genomes to understand better how zoonotic lineages of TB adapt to humans as primary hosts. Ancient MTBC genomes will be extracted from archaeological skeletons. The research team focuses on a densely populated city and trade epicenter to determine the breadth of genomic diversity of ancient circulating MTBC strains, some of which were likely imported through long-distance trade. As human populations expand and the interface between humans and wildlife narrows, understanding the genomic underpinnings of zoonotic transmission dynamics will inform public health surveillance measures. The results of these comparisons will help frame future epidemiological, evolutionary biology, and infectious disease research.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
结核分枝杆菌具有全球分布,并且每年感染超过一百万新的人。在接触前的美洲,结核病(TB)感染是由今天在海豹和海狮中发现的菌株引起的。本博士论文项目调查了人畜共患结核病菌株如何适应人类作为主要宿主并在美洲传播。在整个项目中,亚利桑那州立大学的本科生将接受基因组实验室工作和分析方面的培训,由此产生的数据集将用于创建本科生级别的研讨会。该研究团队将通过促进附属各方之间的相互理解和包容性,从而促进机构之间的长期,创新和富有成效的关系,展示公平的国际合作。结核分枝杆菌复合体(MTBC)是指一组引起人类和动物结核病感染的类似病原体。从考古遗迹中提取的基因组表明,人畜共患病谱系在过去是人类结核病感染的原因。然而,今天人类的大多数结核病感染是由M。结核病,人类适应的MTBC谱系。一种适应动物的病原体变成适应人类的病原体的进化步骤还不完全清楚。研究人员将对现代和古代结核分枝杆菌基因组进行比较,以更好地了解结核病的人畜共患病谱系如何适应作为主要宿主的人类。古代MTBC基因组将从考古骨骼中提取。该研究小组专注于人口稠密的城市和贸易中心,以确定古代流通的MTBC菌株的基因组多样性的广度,其中一些可能是通过长途贸易进口的。随着人口数量的扩大以及人类与野生动物之间的界面缩小,了解人畜共患病传播动态的基因组基础将为公共卫生监测措施提供信息。这些比较的结果将有助于制定未来的流行病学,进化生物学和传染病研究。该奖项反映了NSF的法定使命,并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Anne Stone其他文献

A Comparison of Survival Rates for Treatment of Melanoma Metastatic to the Brain
脑转移性黑色素瘤治疗存活率的比较
  • DOI:
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    2.4
  • 作者:
    Anne Stone;J. Cooper;K. Koenig;J. Golfinos;R. Oratz
  • 通讯作者:
    R. Oratz
An Examination of Organ Donation in the News: A Content Analysis From 2005-2010 of the Barriers to Becoming an Organ Donor
新闻中的器官捐献审视:2005-2010年器官捐献障碍的内容分析
  • DOI:
    10.5772/32665
  • 发表时间:
    2012
  • 期刊:
  • 影响因子:
    0
  • 作者:
    B. Quick;Nicole R. LaVoie;Anne Stone
  • 通讯作者:
    Anne Stone

Anne Stone的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Anne Stone', 18)}}的其他基金

Doctoral Dissertation Research: Ancient Genomics and the Molecular Mechanisms of Human Tolerance to Arsenic
博士论文研究:古代基因组学与人类砷耐受的分子机制
  • 批准号:
    2142160
  • 财政年份:
    2022
  • 资助金额:
    $ 3.14万
  • 项目类别:
    Standard Grant
EAGER: Collaborative Research: Proteomic Detection of Amelogenin Proteins for Biological Profiles
EAGER:合作研究:通过蛋白质组学检测牙釉蛋白的生物学特征
  • 批准号:
    1825055
  • 财政年份:
    2018
  • 资助金额:
    $ 3.14万
  • 项目类别:
    Standard Grant
Doctoral Dissertation Improvement Award: DNA Analysis As A Tool For Understanding Population Movement
博士论文改进奖:DNA分析作为理解人口运动的工具
  • 批准号:
    1622479
  • 财政年份:
    2016
  • 资助金额:
    $ 3.14万
  • 项目类别:
    Standard Grant
Ancient American tuberculosis: origin(s), spread, and replacement
古代美国结核病:起源、传播和替代
  • 批准号:
    1515163
  • 财政年份:
    2015
  • 资助金额:
    $ 3.14万
  • 项目类别:
    Continuing Grant
Doctoral Dissertation Improvement: The origins and dispersal of ancient leishmaniasis in the New World: A bioarchaeological and molecular approach
博士论文改进:新大陆古代利什曼病的起源和传播:生物考古学和分子方法
  • 批准号:
    1232582
  • 财政年份:
    2012
  • 资助金额:
    $ 3.14万
  • 项目类别:
    Standard Grant
Doctoral Dissertation Improvement Grant: Primate Interspecific Interactions
博士论文改进补助金:灵长类动物种间相互作用
  • 批准号:
    1061508
  • 财政年份:
    2011
  • 资助金额:
    $ 3.14万
  • 项目类别:
    Standard Grant
An investigation of the evolutionary history of tuberculosis using ancient DNA
利用古代 DNA 研究结核病的进化史
  • 批准号:
    1063939
  • 财政年份:
    2011
  • 资助金额:
    $ 3.14万
  • 项目类别:
    Continuing Grant
Evolutionary history of tuberculosis: An ancient DNA approach
结核病的进化史:古老的 DNA 方法
  • 批准号:
    0612222
  • 财政年份:
    2006
  • 资助金额:
    $ 3.14万
  • 项目类别:
    Continuing Grant
Doctoral Dissertation Research: Genetic Adaptation to Disease: Tuberculosis Susceptibility in Native South Americans
博士论文研究:疾病的遗传适应:南美洲原住民的结核病易感性
  • 批准号:
    0334849
  • 财政年份:
    2004
  • 资助金额:
    $ 3.14万
  • 项目类别:
    Standard Grant
Genetic history of Peru
秘鲁的遗传史
  • 批准号:
    0242958
  • 财政年份:
    2003
  • 资助金额:
    $ 3.14万
  • 项目类别:
    Continuing Grant

相似海外基金

Doctoral Dissertation Research: How New Legal Doctrine Shapes Human-Environment Relations
博士论文研究:新法律学说如何塑造人类与环境的关系
  • 批准号:
    2315219
  • 财政年份:
    2024
  • 资助金额:
    $ 3.14万
  • 项目类别:
    Standard Grant
Doctoral Dissertation Research: Determinants of social meaning
博士论文研究:社会意义的决定因素
  • 批准号:
    2336572
  • 财政年份:
    2024
  • 资助金额:
    $ 3.14万
  • 项目类别:
    Standard Grant
Doctoral Dissertation Research: Assessing the chewing function of the hyoid bone and the suprahyoid muscles in primates
博士论文研究:评估灵长类动物舌骨和舌骨上肌的咀嚼功能
  • 批准号:
    2337428
  • 财政年份:
    2024
  • 资助金额:
    $ 3.14万
  • 项目类别:
    Standard Grant
Doctoral Dissertation Research: Aspect and Event Cognition in the Acquisition and Processing of a Second Language
博士论文研究:第二语言习得和处理中的方面和事件认知
  • 批准号:
    2337763
  • 财政年份:
    2024
  • 资助金额:
    $ 3.14万
  • 项目类别:
    Standard Grant
Doctoral Dissertation Research: Renewable Energy Transition and Economic Growth
博士论文研究:可再生能源转型与经济增长
  • 批准号:
    2342813
  • 财政年份:
    2024
  • 资助金额:
    $ 3.14万
  • 项目类别:
    Standard Grant
Doctoral Dissertation Research: Do social environments influence the timing of male maturation in a close human relative?
博士论文研究:社会环境是否影响人类近亲的男性成熟时间?
  • 批准号:
    2341354
  • 财政年份:
    2024
  • 资助金额:
    $ 3.14万
  • 项目类别:
    Standard Grant
Doctoral Dissertation Research Improvement Grant: Biobanking, Epistemic Infrastructure, and the Lifecycle of Genomic Data
博士论文研究改进补助金:生物样本库、认知基础设施和基因组数据的生命周期
  • 批准号:
    2341622
  • 财政年份:
    2024
  • 资助金额:
    $ 3.14万
  • 项目类别:
    Standard Grant
Doctoral Dissertation Research: Obstetric constraints on neurocranial shape in nonhuman primates
博士论文研究:非人类灵长类动物神经颅骨形状的产科限制
  • 批准号:
    2341137
  • 财政年份:
    2024
  • 资助金额:
    $ 3.14万
  • 项目类别:
    Standard Grant
Doctoral Dissertation Research: Human mobility and infectious disease transmission in the context of market integration
博士论文研究:市场一体化背景下的人员流动与传染病传播
  • 批准号:
    2341234
  • 财政年份:
    2024
  • 资助金额:
    $ 3.14万
  • 项目类别:
    Standard Grant
Doctoral Dissertation Research: Assessing the physiological consequences of diet and environment for gorillas in zoological settings
博士论文研究:评估动物环境中大猩猩饮食和环境的生理后果
  • 批准号:
    2341433
  • 财政年份:
    2024
  • 资助金额:
    $ 3.14万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了