Cancer Biology Training Program

描述(由申请人提供)：艾普利研究所是内布拉斯加州大学医学中心(UNMC)的一个学术单位，其唯一的重点是基础癌症研究。它是NCI指定的UNMC Eppley癌症中心的主要组成部分。UNMC在中心地带的6个州拥有两个NCI指定的癌症中心之一，并有超过125名教职员工参与实验室和临床研究。因此，Eppley研究所和癌症研究培训计划(CRTP)在培训未来的基础和临床科学家方面发挥着重要的地区性作用。我们从全国博士后和博士后研究员中招募人才。NCI培训补助金支持CRTP的一个关键部分，该项目目前有26名博士后研究员和42名博士后研究员正在接受培训。CRTP教员在广泛的癌症研究培训计划的重要领域拥有广泛的专业知识，包括生物化学、细胞和结构生物学、药物输送、遗传学、免疫学、有机和药物化学、病理药剂学和药效学、药理学和临床肿瘤学。Eppley研究所的CRTP不授予博士学位，所有进入CRTP的研究生都有机会与CRTP的教职员工轮流工作，然后再在参与的系中挑选论文导师：生物化学和分子生物学、病理学和微生物学、药学和药理学。我们的许多受训人员直接参与了翻译研究活动，例如白血病的基因靶向治疗、儿茶酚雌激素在人类乳腺癌中的作用、放射免疫结合治疗和肿瘤疫苗开发、妇科癌症肿瘤标记物的开发。培训基金的目标是为每一位博士生和博士后提供知识基础、实验室技能和解决问题的能力，以成为独立的、创新的癌症研究人员。CRTP的具体目标是为博士后和博士后学员提供：(1)癌症发生机制、人类癌症流行病学和癌症预防潜力的知识；(2)基础科学(生物化学和分子生物学、遗传学、免疫学、病理学、药学、药理学)领域的深入背景，这是研究和理解正常细胞转化为癌细胞并设计诊断和治疗方法所必需的；(3)能够应用这些信息来计划和进行关于癌症原因、预防、诊断和治疗的创新研究；以及(4)对跨学科研究的力量的欣赏。为了实现这些目标，CRTP必须能够吸引高素质和积极进取的研究生和博士后研究员，并为他们提供高质量的教学和实验室经验。

DESCRIPTION (provided by applicant): The Eppley Institute is an academic unit of the University of Nebraska Medical Center (UNMC) with its sole focus on basic cancer research. It is a major component of the NCI-designated UNMC Eppley Cancer Center. UNMC has one of two NCI-designated Cancer Centers in a 6 state region of the heartland and has more than 125 faculty members involved in laboratory and clinical research. As such, the Eppley Institute and the Cancer Research Training Program (CRTP) play an important regional role in training future basic and clinical scientists. We recruit from a national pool of predoctoral and postdoctoral fellows. The NCI Training Grant supports a key part of the CRTP, which currently has 26 predoctoral and 42 postdoctoral fellows in training. The CRTP faculty have a wide variety of expertise in areas important for a broad-based cancer research training program, including biochemistry, cellular and structural biology, drug delivery, genetics, immunology, organic and medicinal chemistry, pathology pharmaceutics and pharmacodynamics, pharmacology, and clinical oncology. The Eppley Institute's CRTP does not grant a doctoral degree, and all entering graduate students have a chance to rotate with CRTP faculty before they pick a thesis advisor in one of the participating departments: Biochemistry and Molecular Biology, Pathology and Microbiology, Pharmaceutical Sciences, and Pharmacology. A number of our trainees are directly involved in translational research activities, e.g., gene-targeted therapy for leukemia, role of catechol estrogens in human breast cancer, radioimmunoconjugate therapy and tumor vaccine development, development of tumor markers for gynecologic cancer. The goal of the training grant is to provide each doctoral student and postdoctoral fellow with the knowledge base, laboratory skills, and problem solving abilities to become independent, innovative cancer investigators. The specific aims of the CRTP are to provide pre- and postdoctoral trainees with: (1) knowledge of the mechanisms of carcinogenesis, the epidemiology of human cancer, and the potential for cancer prevention; (2) an in-depth background in the areas of basic science (biochemistry and molecular biology, genetics, immunology, pathology, pharmaceutical sciences, pharmacology) that is necessary to study and understand the conversion of normal cells to cancer cells and to design methods of diagnosis and treatment; (3) the ability to apply this information to plan and conduct innovative research on the causes, prevention, diagnosis and treatment of cancer; and (4) an appreciation of the power of interdisciplinary research. To achieve these aims the CRTP must be able to attract highly qualified and motivated graduate students and postdoctoral fellows and provide them with high quality didactic and laboratory experiences.