Reduced Interneuronal Space in Schizophrenic Brains

描述：(申请人提供)据推测，前额叶 精神分裂症患者大脑皮层的神经元间隙比对照组小， 特别是在第9区和第46区。这被认为反映了 根据Selemon等人的说法，这些区域的神经元电路。(1995)是一个 可能是精神分裂症病理的组成部分。这项研究，以及那些 然后，是基于神经元密度的测量。我们的目标是 两个方面：一是基于皮质微柱检查这一发现，以及 第二，阐明神经元间隙的分布。 细胞柱的形态。我们的初步研究使用了一种小的 正常对照组(n=16)和精神分裂症患者(n=9)。 按DSM ffl-R诊断标准诊断。我们的测试显示的值较小 精神分裂症患者脑区9区的所有间距和神经束间距。这个 最大的降幅出现在微柱隔间，其中大多数 顶端树突束、丘脑皮质和皮质-皮质纤维 找到了。这项研究将检查40例精神分裂症患者(DSM IV)的柱状差异 诊断)和来自Runwell IFI收集的52个对照。标本 将从第9区、第46区、第17区和第4区(布罗德曼)得出。放大图像(10OX) 将对III-VI层中Nissi染色的细胞柱进行分析 计算机成像硬件和软件使研究人员能够准确地 量化细胞柱形态的细节。体视学技术将是 用来估计神经元密度。如果我们的初步发现是 得到证实，比正常小的柱子会显示出 大脑回路的重组很可能是在发育过程中定义的。

DESCRIPTION: (provided by applicant) It has been postulated that the prefrontal cortices of schizophrenic patients have less interneuronal space than controls, specifically in areas 9 and 46. This is thought to reflect an alteration in the neuronal circuitry of these areas that according to Selemon et al. (1995) is a possible component of the pathology of schizophrenia. This study, and those that followed, were based on measures of neuronal density. Our goal is two-fold: one is to examine this finding based on the cortical minicolumn, and secondly, to elucidate the distribution of interneuronal space in regards to the morphology of the cell column. Our preliminary study used a small population of normal controls (n = 16) and schizophrenic patients (n = 9), diagnosed according to DSM ffl-R criteria. Our test revealed smaller values for all spacing distances and neuropil space in area 9 of schizophrenic brains. The greatest reduction occurred in the minicolumn compartment where the majority of apical dendrite bundles, thalamocortical, and cortico-cortical fibers are found. This study will examine columnar differences in 40 schizophrenic (DSM IV diagnosis) and 52 controls derived from the Runwell ifi collection. Specimens will be derived from areas 9, 46, 17, and 4 (Brodmann). Magnified images (lOOx) of Nissi-stained cell columns in layers III-VI will be analyzed by powerful computer imaging hardware and software enabling researchers to precisely quantify details of cell column morphology. Stereological techniques will be used to estimate neuronal density. If our preliminary findings are corroborated, the smaller than normal minicolumns will demonstrate a reorganization of brain circuitry most probably defined during development.