Midcareer Award in Patient-Oriented Research

描述（由申请人提供）：本临床研究职业中期研究者奖的目的是提供约翰欧文，医学博士，伯明翰亚拉巴马大学（UAB）医学院妇产科教授，有足够的保护时间1）继续和扩大其正在进行的临床研究活动，包括担任受资助的U 01多中心随机环扎术预防自发性早产试验的主要研究者; 2）提高他作为导师和教育者的能力，特别是通过完成临床研究硕士学位和获得UAB生物统计学系的双重任命;和3）继续通过Ob/Gyn住院医师的研究计划，特别是通过他作为UAB母胎医学奖学金项目主任的职位，识别和培训学术重点个人。他的新技能收购的重点将是在最近由公共卫生和生物统计学院联合推出的一个新的研究生课程临床研究硕士学位的完成。它专门针对最近的NIH目标，通过结合生物统计学和公共卫生课程的选定方面，扩大合格的临床研究人员的人才库，提供更广泛，更务实的教育经验。欧文可以保证在生物统计学院的双重任命，并将在这个有价值的计划中承担正式的，持续的教学承诺。此外，作为P.I.在最近资助的U 01赠款中，他将在妊娠中期宫颈长度缩短的高危妇女中进行环扎术的多中心随机试验，他将处于战略地位，在多胎妊娠妇女中开展类似的试验，并获得计划作为随机试验一部分的生物流体库分析的资金。这将增加我们对复发性自发性早产机制的理解，并为多个研究项目提供基础，通过这些项目，欧文博士可以与其他年轻的研究人员合作，从而培训他们。总之，上述举措，再加上他作为UAB的母胎医学奖学金和产科住院研究单位的主任，并由职业中期研究者奖担保，将确保他的教育和经验将通过不断培养其他研究事业来传播。

DESCRIPTION (provided by applicant): The purpose of this Mid-career Investigator Award in Clinical Research is to provide John Owen, M.D., Professor of Obstetrics and Gynecology in the School of Medicine at the University of Alabama at Birmingham (UAB) with sufficient protected time to 1) continue and expand his ongoing clinical research activities including serving as the principal investigator of a funded U01 multicenter randomized trial of cerclage for the prevention of spontaneous preterm birth; 2) enhance his capabilities as a mentor and educator, especially through the completion of an MPH in Clinical Research and receipt of a dual appointment in the Department of Biostatistics at UAB; and 3) continue to identify and train academically focused individuals through research initiatives in the Ob/Gyn residency and particularly through his position as the Maternal-Fetal Medicine fellowship program director at UAB. The focus of his new skills acquisition will be the completion of an MPH in Clinical Research in a novel post-graduate program recently introduced jointly by the schools of Public Health and Biostatistics. It specifically addresses recent NIH goals to expand the pool of qualified clinical investigators by combining selected aspects of both the Biostatistics and Public Health curricula, offering a broader and more pragmatic educational experience. With this advanced degree, Dr. Owen can be assured of a dual appointment in the School of Biostatistics and will assume a formal, ongoing teaching commitment in this valuable program. Moreover, as the P.I. of a recently funded U01 grant to conduct a multicenter randomized trial of cerclage in high-risk women with shortened mid-trimester cervical length, he will be in a strategic position to launch a similar trial in women with multiple gestation and also to receive funding for the analysis of the biologic fluid bank planned as part of the randomized trial. This will increase our understanding of the mechanisms of recurrent spontaneous preterm birth and also provide the basis for multiple research projects through which Dr. Owen can collaborate with and thereby train other young investigators. In summary, the above-stated initiatives, coupled with his position as the director of both the Maternal-Fetal Medicine fellowship and the obstetric in-patient research unit at UAB, and secured by the Mid-career Investigator Award, will ensure that his education and experience will be propagated by continuously fostering other research careers.