OHSU HUMAN INVESTIGATIONS PROGRAM

在分子和细胞生物学，信息学和临床试验在过去的二十年中的许多进步已经提出了一套新的研究技能，为当前和未来的临床研究人员掌握额外的要求。不幸的是在临床研究者成功职业所必需的技能变得更广泛的时候，来自医师临床研究者的NIH资助申请数量一直在减少。在美国，以病人为导向的研究很可能会继续受到影响，除非认真努力增加计划从事人体研究的临床研究人员的数量和能力水平。该奖项中概述的培训计划是对加强技能建设和增加临床研究人员数量的需求的及时和具体的回应。俄勒冈州健康科学大学（OHSU）装备精良，为临床研究人员提供全面的培训，教授必要的研究技能，并提供广泛的人类研究基础。OHSU人类研究计划的具体目标源于以下假设：所有临床研究者都必须具备核心技能;这种技能可以教授;来自各种背景的研究者的技能相似;研究技能的重点应该基于将基本科学思想转化为床边的需要。该申请的目的包括：增加西北地区成功的，全面培训的临床研究人员的数量;通过为临床研究员和初级教师提供正式课程，增强和丰富OHSU人类研究的当前培训活动;提供指导培训部分，以进一步促进学习者的发展;以及，创建一个基于Web的学习计划，允许受临床时间表或地理限制限制的学习者参与。我们的活动将利用基于问题的学习技术和正式的教学课程，这些课程将根据临床研究者学员的需求量身定制。我们的努力将有助于国家运动，以增加临床研究人员的规模，以及对人类研究为基础的职业感兴趣的年轻临床研究人员的能力水平。

The many advances in molecular and cell biology, in informatics, and in Clinical trials over the past twenty years have placed additional demands for mastery of a new set of research skills for current and future clinical investigators. Unfortunately. at the time when the necessary skills for successful careers for clinical investigators have become broader, the numbers of NIH grant applications from physician clinical investigators has been decreasing. Patient oriented research in the U.S. is likely t6 continue to suffer unless serious efforts are aimed at increasing the number and the level of competency of clinician investigators who plan careers in human investigation. The training program outlined in this award is a timely and specific response to the need to enhance skill building and to increase the number of clinical investigators. Oregon Health Sciences University (OHSU) is well equipped to provide comprehensive training to clinical investigators, to teach necessary research skills, and to offer a broad foundation in human investigations. The specific aims of the OHSU Human Investigations Program derive from the hypotheses that a core skill set is necessary for all clinical investigators; that this skill set can be taught; that the skills are similar for investigators from a variety of backgrounds; and that the focus of the research skill set should be based on the need to translate basic science ideas to the bedside. The aims of this application include: increasing the number of successful, comprehensively trained clinical investigators in the Northwest; augmenting and enriching the current training activities in human investigations at OHSU by offering a formal curriculum for clinical fellows and Junior faculty; providing a mentored training component to further learner development; and, creating a Web-based learning program that will allow participation of learners who are limited by clinical schedules or by geographic constraints. Our activities will make use of problem-based learning techniques and formal didactic sessions that will be well-tailored to the needs of the clinical investigator trainees. Our efforts will assist the national movement to increase the size of the clinical investigator pool, as well as the level of competency of young clinical researchers who are interested in human investigations-based careers.