CORE--SCIENTIFIC/CLINICAL

科学-临床核心有运动神经元疾病(MND)诊所作为 它的核心资源。该诊所评估MND患者并收集和 向项目资助计划的成员分发临床标本。 临床对家族性病例、不典型的MND特别感兴趣。 患者、脊髓灰质炎后患者和病毒性肺炎或 免疫异常。该诊所还参与了以下工作 领域：(A)家族性MND研究，(B)Dimmune分析 MND异常，(C)神经生理、形态和 脊髓灰质炎后综合征的免疫学研究，(D)获得 MND患者的尸检组织，(E)对患者态度的研究 患者、家庭和医生对MND的生命维持支持， (F)执行实验性治疗方案；(G)教育 MND患者和家属，以及住院医生、研究员和 辅助医疗人员在诊断和护理MND患者中的作用。这个 科学核心也是血清、脊髓液和 来自经过良好评估的患者的尸检组织，供广大调查人员使用。

The Scientific-Clinical core has a Motor Neuron Disease (MND) Clinic as its central resource. The clinic evaluates MND patients and collects and distributes clinical specimens to members of the Program Project Grant. The clinic has a special interest in familial cases, atypical MND patients, post-poliomyelitis patients, and patients with viral or dysimmune abnormalities. The clinic is also involved in the following areas: (a) studies of familial MND, (b) an analysis of dysimmune abnormalities in MND, (c) neurophysiological, morphological and immunological studies of post-poliomyelitis syndrome, (d) acquisition of autopsy tissues from MND patients, (e) studies of the attitudes of patients, families and physicians towards life-sustaining support in MND, (f) implementation of experimental treatment protocols, (g) education of MND patients and families, and training of residents, fellows, and paramedical individuals in the diagnosis and care of MND patients. The Scientific core also stands as a repository of sera, spinal fluids and autopsy tissues from well-evaluated patients for investigators at large.