CORE--PRIMATE

描述(由申请人提供)：该核心的目标是为 人类和非人类灵长类避孕药目标研究中心，以及测试避孕剂在灵长类动物中的有效性中心。具体地说，该中心的目标是：1.提供将概念和产品从基础研究中心项目应用到人类避孕开发所需的组织结构和专业知识。2.为生化和分子生物学研究提供实验室资源，以确定中心项目在小鼠模型中确定的避孕靶标的人和非人灵长类同源物。3.提供非人类灵长类动物资源，用于初步测试避孕药及其分娩方法的安全性。4.提供生物材料，包括来自人类和非人类灵长类动物的组织、体液和配子，用于体外避孕行动的测试。5.提供在非人类灵长类动物中进行大规模繁殖研究所需的设施和专门知识，以确定避孕药的有效性和安全性。

DESCRIPTION (provided by applicant): The objectives of this Core are to provide resources to the Center for studies of contraceptive targets in humans and non-human primates and for testing the effectiveness of contraceptive agents in primates. Specifically, the objectives of the Core are: 1. To provide the organizational structure and expertise required for application of concepts and products from basic research in Center Projects to human contraceptive development. 2. To provide a laboratory resource for biochemical and molecular biology studies to identify human and non-human primate homologs of contraceptive targets identified by Center Projects in the mouse model. 3. To provide an animal resource of non-human primates for preliminary testing of the safety of contraceptive agents and methods for their delivery. 4. To provide biological materials including tissues, body fluids and gametes from humans and non-human primates for in vitro assays of contraceptive actions. 5. To provide the facilities and expertise required for large-scale breeding studies with non-human primates to determine the efficacy and safety of contraceptive agents.