CORE--NMR

描述：（申请人的描述）分子NMR共享设施具有 以下目标：1.提供仪器，供 UAB综合癌症中心的成员在他们的研究计划;和 2.为癌症中心成员提供核磁共振专业知识， 协商 在上一个供资期间，85.5%的基金使用量是由 癌症中心的教职员工。这些机构进行的一些调查 核磁共振设备的教员参与了肽的设计工作 调节钙调蛋白活性的双功能螯合剂的设计， 放射性标记的单克隆抗体，核苷类似物的设计， 抗癌药物，干扰素-tau的结构研究，结构 神经毒素和钠通道胞外结构域、抑制剂的研究 流感病毒神经氨酸酶，载脂蛋白片段， 蛋白多糖，类维生素A的表征，糖基化对 c-Myc，使用RNA-DNA三链体的抗基因治疗，病毒的结构研究 支架蛋白和神经毒素有效对抗神经胶质瘤。的NMR 该设施的系统也正在升级，以提供最先进的 为设施的使用者提供服务。继续支持这些 研究项目的NMR设施提出。

Description: (Applicant's Description) The Molecular NMR Shared Facility has the following objectives: 1. To provide instrumentation for use by the members of the UAB Comprehensive cancer Center in their research programs; and 2. To provide NMR expertise to the Cancer Center members through service and consultation. During the previous funding period, 85.5 percent of the Facility usage was by Cancer Center faculty members. Some of the investigations conducted by these faculty members at the NMR Facility involved work on the design of peptides that regulate calmodulin activity, design of bifunctional chelating agents for radiolabeling monoclonal antibodies, design of nucleoside analogs as anticancer drugs, structural investigations on interferon-tau, structural studies on neurotoxins and sodium channel extracellular domains, inhibitors of influenza virus neuraminidase, apolipoprotein fragments, biosynthesis of proteoglycans, characterization of retinoids, effect of glycosylation on c-Myc, antigene therapy using RNA-DNA triplexes, structural studies of viral scaffolding proteins, and neurotoxins effective against glioma. The NMR systems at the Facility are also being upgraded to provide state-of-the-art capabilities to the users of the Facility. Continued support of these research projects by the NMR Facility is proposed.