Mutidisciplinary Training; Brain Disorders & Development

描述(由申请人提供) 这个新的博士后项目的目标是培养年轻的科学家， 特别是内科科学家，并促进专注于理解 发育中神经系统紊乱的基本机制。 多学科培训计划在有关科学学科中进行 神经发育障碍的研究。因此，19名培训教师被选中。 来自5个部门。教职工包括4名医学博士、2名医学博士和13名博士。他们的 职级为：11名教授、3名副教授和5名助理教授。 斯旺博士将担任项目主任，负责日常工作 程序的运行。佐格比博士和诺贝尔斯博士将担任 联席董事。主要培训领域包括遗传和分子基础 遗传性神经发育障碍包括：Rett综合征，Angelman‘s 综合征、脆性X综合征、唐斯综合征、Miller-Dicker脑白质畸形和 泛发性棘波癫痫。另一个共同的研究重点将是 神经科学实验室使用先进的成像技术和 研究细胞和分子的电生理学技术 与遗传性和获得性癫痫慢性模型相关的异常 精神错乱。教员的所有实验室都提供专业知识 用于创建和研究动物模型的尖端生物技术。三 计划了单独的培训轨道。一种适用于医学博士和医学博士 具有丰富的基础科学研究经验。另一种是针对经验较少的人 MDS和第三个博士学位。这些医学博士研究生将得到以下建议： 个性化的研究咨询委员会选择他们的实验室 轮换和研究生水平课程。博士将在以下方面接受大量培训 神经发育障碍的临床表现 会议、专科诊所和医院查房。贝勒学院 医学投入了大量的资源用于基础研究 疾病的机制，包括发育中的大脑的机制。实验室 空间和核心实验室是杰出的。儿科神经科诊所， 实验室和中心，包括美国国立卫生研究院资助的智力低下研究 中心，将是博士后实习生的重要资源。确实有 目前有84名博士后在培训学院的实验室里， 其中医学博士14人，医学博士8人，博士62人。通过培训新一代 杰出的研究科学家，我们希望新的治疗方法和 治愈婴儿和幼儿的破坏性发育障碍将 浮出水面。

DESCRIPTION (provided by applicant) The goal of this new postdoctoral program is to train young scientists, particularly physician scientists, and promote careers focused on understanding the basic mechanisms underlying disorders of the developing nervous system. Multidisciplinary training is planned in scientific disciplines relevant to the study of neurodevelopmental disorders. Thus, 19 training faculty were selected from 5 departments. The faculty includes 4 MDs, 2 MD/Ph.Ds and 13 Ph.Ds. Their ranks are: 11 Professors, 3 Associate Professors and 5 Assistant Professors. Dr. Swann will serve as Program Director and be responsible for the day-to-day operation of the program. Dr. Zoghbi and Dr. Noebels will serve as Co-Directors. Major training areas include the genetic and molecular basis of inherited neurodevelopmental disorders including: Rett Syndrome, Angelman's Syndrome, Fragile X Syndrome, Downs Syndrome, Miller-Dicker Lissencephaly and Generalized Spike-Wave Epilepsy. Another, shared focus of study will be epilepsy where neuroscience laboratories use advanced imaging and electrophysiological techniques to study the cellular and molecular abnormalities relevant to chronic models of both inherited and acquired seizure disorders. All the laboratories of the faculty provide expertise in cutting-edge biotechnology for the creation and study of animal models. Three separate training tracks are planned. One is for MD/PhDs and MDs with substantial basic science research experience. Another is for less experienced MDs and the third for PhDs. These latter MD students will be advised by individualized research advisory committees on their choice of laboratory rotations and graduate level courses. PhDs will receive substantial training in the clinical aspects of neurodevelopmental disorders through clinical conferences, subspeciality clinics and hospital rounds. Baylor College of Medicine has committed substantial resources to the study of the basic mechanisms of diseases including those of the developing brain. Laboratory space and core laboratories are outstanding. Pediatric Neurology clinics, laboratories and centers, including a NIH funded Mental Retardation Research Center, will be important resources for postdoctoral trainees. There are currently 84 postdoctoral students in the laboratories of the training faculty, including 14 MD/PhDs, 8 MDs and 62 PhDs. By training a new generation of outstanding research scientists, we hope new approaches for the treatment and cure of devastating developmental disorders in infants and young children will emerge.