BIOACTIVE COMPOSITE COATINGS FOR IMPLANTS

描述(改编自《调查者摘要》)：种植材料 代表着极端的挑战，因为它们必须满足许多相互冲突的 要求。没有一种材料可以满足所有这些要求，而且通常只有一种材料可以满足这些要求 再涂上一层。在这一点上，涂层代表了更多的材料挑战 它们需要结合到底物上，同时保持其主要功能 属性。这在用金属合金替代骨的情况下是正确的 维持骨骼负荷所需的结构特性被涂有 羟基磷灰石类材料改善骨整合和生物固定 剩下的骨头。申请者的策略是在钛及其合金上涂覆一层 使用由汉奇开发的生物活性玻璃改装而成。可靠地 在模拟人体中形成磷灰石的附着涂层已经被生产出来 流体。这种玻璃已被证明可以促进骨肉瘤细胞的黏附， 这在骨整合方面很有希望。拟议的研究将优化 钛表面生物活性涂层及钴铬类似涂层的性能 合金。将使用功能梯度和复合材料来生产 具有生物活性和生物吸收率等特制性能的涂料。 功能梯度材料(FGM)涂层，包含玻璃和 将制备羟基磷灰石(HA)和磷酸三钙(TCP)。涂料 将通过扫描电子显微镜、透射电子显微镜和X射线衍射仪进行分析，以确定界面上的反应 使用金属，也在涂层内。女性生殖器切割的底层将是 选择用于粘附性，并通过俄歇和XPS进行分析。的顶端 功能梯度材料将在模拟体液(SBF)中通过老化进行研究，随后 通过测定HA的溶解度和生成程度。组织培养 测试将被用来确定最佳表面粗糙度和活体研究 将被用来通过组织形态学检查骨-种植体界面， 组织学、扫描电子显微镜和拔出试验。建议进行研究，以制定一种明确的 对涂层结构稳定性和附着力的机理理解 金属底座。因此，涂层的机械性能 并将确定它们的界面和显微组织-性能 为指导临床医生选择材料而发展的关系。 断裂力学模型和技术将被应用于评价 强度/缺陷交互作用、断裂韧性和应力腐蚀裂纹 成长。由于人体将使用涂层，几乎所有这些技术都将 扩展到包括循环疲劳条件。

DESCRIPTION (Adapted from the Investigator's Abstract): Implant materials represent an extreme challenge since they must satisfy many conflicting requirements. No one material can meet them all, and often one material is coated with another. The coatings represent further material challenges in that they need to bond to the substrate while maintaining their primary functional properties. This is true in the replacement of bone where metal alloys, with the structural properties needed to sustain skeletal loading, are coated with hydroxyapatite-like materials to improve osseointegration and biofixation with the remaining bone. The applicant's strategy has been to coat Ti and its alloys with bioactive glasses modified from those developed by Hench. Reliably adherent coatings have been produced that form apatite in a simulated body fluid. The glasses have been shown to promote adherence of osteosarcoma cells, which is promising for osseointegration. The proposed research will optimize the properties of bioactive coatings on Ti and similar coatings on Co-Cr alloys. Functionally graded and composite materials will be used to produce coatings with tailored properties such as bioactivity and bioresorptivity. Functionally graded materials (FGM) coatings containing glasses and hydroxyapatite (HA) and tricalcium phosphate (TCP) will be prepared. Coatings will be analyzed by SEM, TEM, and XRD to identify reactions at the interface with metal and also within the coating. The bottom layer of the FGM will be selected for adherence properties and be analyzed by Auger and XPS. The top of the FGM will be studied through aging in simulated body fluid (SBF), followed by a determination of the solubility and extent of HA formation. Tissue culture tests will be used to determine optimal surface roughness and in vivo studies will be used to examine the bone-implant interface through histomorphology, histology, SEM, and pullout tests. Studies are proposed to develop a clear mechanistic understanding of coating structural stability and adherence to metal substructures. Consequently, the mechanical properties of the coatings and their interfaces will be determined and microstructure-property relationships developed to guide clinicians in their choice of materials. Fracture mechanics models and techniques will be applied to the evaluation of strength/flaw interactions, fracture toughness, and stress corrosion crack growth. As coatings will be used in the body, nearly all these techniques will be expanded to involve cyclic fatigue conditions.