PROSPECTIVE INVESTIGATION OF PUMONARY EMBOLISM DX II

一项多中心协作研究，旨在确定对比增强螺旋计算机断层扫描（螺旋CT）诊断急性肺栓塞（PE）的敏感性、特异性、阳性预测值和阴性预测值。肺栓塞是常见的，但往往无法诊断和致命的。通气/灌注肺扫描是最常用的测试。然而，在72%的疑似PE患者和57%的确诊PE患者中，它们是非诊断性的。目前，肺血管造影术是确定的诊断测试，但是，由于发病率，不适，不适，成本和社区医院缺乏可用性，使用它犹豫不决。对比增强螺旋CT是一种几乎无创的检查，通过显示肺动脉血栓的轮廓，提供了明确诊断PE的可能性。然而，其在PE诊断中的效用尚不清楚。尽管空间CT尚未得到充分验证，但许多医院的医生现在将其用作PE的明确且唯一的诊断测试，或用作通气/灌注肺扫描无法诊断的患者的明确测试。这可能导致过度治疗或治疗不足，两者都有可能导致严重并发症。螺旋CT在PE诊断中的作用需要准确的血管造影。该提案的优势在于：1）PE问题在因诊断不足而失去生命方面的重要性2）用于诊断PE的新技术的潜在适用性，该技术将具有广泛的可用性3）调查团队。

A multi-center collaborative study to determine the sensitivity, specificity, positive predictive value and negative predictive value of contrast enhanced spiral computed tomography (spiral CT) for diagnosis of acute pulmonary embolism (PE). Pulmonary embolism is common, yet frequently undiagnosed and fatal. Ventilation/perfusion lung scans are the most commonly used test. However, they are non-diagnostic in 72% of patients with suspected PE and in 57% of patients with proven PE. Currently, Pulmonary Angiography is the definitive diagnostic test, but, there is hesitancy to use it because of morbidity, discomfort, discomfort, cost and lack of availability in community hospitals. Contrast enhanced spiral CT is a nearly non-invasive test that offers the possibility of a definitive diagnosis of PE by showing the outline of the thrombus in a pulmonary artery. However, its utility in the diagnosis of PE is unknown. Although spatial CT has not been adequately validated, physicians at many hospitals now use it as a definitive and only diagnostic test for PE, or as a definitive test in patients in whom the ventilation/perfusion lung scan is non-diagnostic. This could lead to over-treatment or under- treatment, of which, both have potential for serious complications. The role of spiral CT in the diagnosis of PE requires an accurate angiography. The strengths of this proposal are: 1) the importance of the problem of PE in terms of lives lost from under-diagnosis 2) the potential applicability of a new technology for the diagnosis of PE that will have widespread availability 3) the investigation team.