Genetics of ADHD

贝利-威尔逊博士是一项关于注意力缺陷多动障碍的合作研究的成员。NHGRI的Max Muenke和Kate Berg以及哥伦比亚大学的Mauricio Arcos-Burgos博士。贝利-威尔逊博士的角色是帮助研究设计，并在项目中担任统计遗传学家。在过去，我们对来自哥伦比亚大学的许多大型家系进行了功率研究，结果表明，即使存在异质性，在连锁研究中也有足够的功率来检测中等到较大影响的基因。贝利-威尔逊博士还就谱系结构的类型向其他合作者提供建议，这些谱系结构对连锁研究尤其有用。一篇详细介绍研究设计和仿真的论文已经提交。在本财政年度，对哥伦比亚大学的第一组大型系谱进行了连锁和关联研究，以确定几个候选位点的标记。报告这些结果的手稿正在准备中。

Dr. Bailey-Wilson is a member of a collaborative study of Attention Deficit Hyperactivity Disorder, collaborating with Drs. Max Muenke and Kate Berg of NHGRI and Dr. Mauricio Arcos-Burgos of Columbia. Dr. Bailey-Wilson's role is to help with study design and to serve as statistical geneticist on the project. In the past, we have performed power studies of many large pedigrees from Columbia, showing that there will be adequate power in a linkage study to detect genes of moderate to large effect, even in the presence of heterogeneity. Dr. Bailey-Wilson also advises the other collaborators about the types of pedigree structures that are particularly informative for linkage studies. A paper detailing the study design and the simulation has been submitted. In this fiscal year, linkage and association studies have been performed on the first set of large pedigrees from Columbia for markers in several candidate loci. A manuscript reporting these results is in preparation.