GENOMIC ANALYSIS OF STRESS AND INFLAMMATION

本申请提出应用高通量的生物发现工具 鉴定和鉴定由PRO激活的基因和基因网络 影响心血管的炎症、代谢和病原体应激 系统和肺。PGA的特点是高度互动的一组 具有重叠兴趣和独特技术的调查人员可以做出贡献 为这些努力干杯。申请者的一个相关且同样重要的目标是 传播工具和试剂以广泛支持学术 研究人员将研究信号转导途径和基因表达 模式使用的工具和方法直到最近都是独一无二的 私营部门的领地。要充分利用这些机会 技术提供，并利用即将完成的 人类和小鼠基因组测序，一个综合的，多学科的 科考队已经组建完毕。

This application proposes to apply high throughput biological discovery tools to identify and characterize genes and gene networks activated by pro- inflammatory, metabolic, and pathogen stresses affecting the cardiovascular system and the lung. The PGA features a highly interactive group of investigators with overlapping interests and unique technologies to contribute to the effort. A related and no less important objective of the applicants is the dissemination of tools and reagents to broadly enable academic investigators to study signal transduction pathways and gene expression patterns using tools and methods that until recently have been the exclusive province of the private sector. To fully exploit the opportunities these technologies offer, and to capitalize on the imminent completion of the sequencing of the human and mouse genomes, an integrated, multi-disciplinary research team has been assembled.