Conformal Array Microwave Radiometer Thermometry Device

描述（由申请人提供）：拟议的II期项目的目标是设计，制造和在动物模型中测试一个灵活的系统，用于快速，准确地非侵入性测量身体大面积的皮肤和皮下组织温度。为了实现这一目标，我们建议将第一阶段开发的双频自校准辐射计与32个微波接收天线一起使用，包括测量皮肤温度的手段，并设计和制造多层薄且柔性的共形阵列天线，不仅可以用于诊断组织温度测量，还可以用于监测和控制现有的微波和超声热疗设备。这项关键技术的应用范围从检测皮下炎症和原发性乳腺癌，到快速监测癌症治疗和抗炎治疗的疗效，再到监测和反馈控制对大面积皮肤的热疗法，如对乳腺癌胸壁复发和斑块性牛皮癣病变的热疗治疗。

DESCRIPTION (provided by applicant): The objective of the proposed Phase II program is to design, fabricate, and test in an animal model a flexible system for the rapid and accurate non-invasive measurement of skin and subsurface tissue temperatures over large areas of the body. To accomplish this objective we propose to adapt the dual-frequency, self-calibrating radiometer developed in Phase I for use with 32 microwave receive antennas, include means for measuring skin temperatures, and to design and fabricate multi-layer thin and flexible conformal array antennas that may be used not only for diagnostic tissue temperature measurements, but also for monitoring and controlling existing microwave and ultrasound hyperthermia treatment devices. Application that are expected to benefit from this critical enabling technology range from the detection of subsurface inflammations and primary breast cancer, to rapid monitoring of the efficacy of cancer treatments and anti-inflammatory therapies, to monitoring and feedback control of heat therapy to large areas of skin such as is required for hyperthermia treatment of chestwall recurrence of breast cancer and plaque psoriasis lesions. PROPOSED COMMERCIAL APPLICATIONS: Potential commercial applications of the conformal radiometer array include devices for monitoring and controlling of superficial hyperthermiua therapies for cancer and psoriasis, for detection and monitoring of sub-surface inflammation and cancer, and for monitoring the efficacy of anti-cancer, anti-inflammatory and blood perfusion enhancing therapies.