Phytoestrogens, alcohol, and endometrial cancer risk

描述（由申请人提供）：这是一个学术职业奖的应用程序，以支持在营养科学系，罗格斯大学的副研究科学家Elisa V. Bandera博士的培训和研究计划。 该计划的目标是：1）通过提供营养，营养流行病学，分子流行病学和癌症流行病学的强大理论基础，补充她以前在医学和流行病学方面的培训; 2）将这种理论培训应用于子宫内膜癌的病例对照研究。 拟议的教育计划包括指导、结构化课程、研讨会、会议和指导性阅读。相关领域的高素质专家团队将通过这些活动指导候选人，并帮助她实现目标。 本申请中提出的研究建立在一项为期五年的基于人群的病例对照研究（Sara OIson博士，PI; R 01 CA 83918）基础上，资助开始日期为2001年7月1日。病例对照研究为拟议的研究提供了背景，包括600例类胶质瘤，200例浆液性或透明细胞肿瘤，以及600例对照。 这些病例将是21岁以上的妇女，居住在新泽西的六个县，患有新诊断的、组织学证实的上皮性子宫内膜癌。 对照组将与病例（+5岁）频率匹配，并通过随机数字拨号（对于65岁以下的患者）或从HCFA文件（对于65岁以上的患者）中选择。 拟议的项目扩大了父母补助金的目标，其主要目标是评估雌激素，遗传学和膳食脂肪的作用。 拟议项目的具体目标是调查植物雌激素和饮酒与子宫内膜癌风险之间的关系。 将研究体重指数、雌激素替代治疗、脂肪和总能量摄入、吸烟、参与雌激素代谢的酶的基因型和组织学类型对可能的影响。 酒精和植物雌激素摄入量之间的相互作用也将被检查。 拟议研究的另一个组成部分是一项可行性研究，以评估一种创新的多媒体网络饮食评估方法，计算机辅助自我采访饮食史，在子宫内膜癌的病例对照研究的背景下。 该奖项将提供候选人在癌症营养流行病学方面发展独立职业所需的支持和培训。

DESCRIPTION (provided by applicant): This is an Academic Career Award application to support a training and research program for Dr. Elisa V. Bandera, an Associate Research Scientist in the Department of Nutritional Sciences, Rutgers University. The goals of this program are: 1) to complement her previous training in medicine and epidemiology by providing a strong theoretical foundation in nutrition, nutritional epidemiology, molecular epidemiology, and cancer epidemiology; and, 2) to apply this theoretical training in a case-control study of endometrial cancer. The proposed educational plan includes mentoring, structured courses, seminars, conferences, and guided readings. A highly qualified team of experts in the relevant areas will mentor the candidate through these activities and help her achieve her goals. The research proposed in this application builds upon a five-year population-based case-control study (Dr. Sara OIson, PI; R01CA83918), with a funding start date of July 1, 2001. The case-control study that provides the context for the proposed research includes 600 cases with endometrioid tumors, 200 with serous or clear cell tumors, and 600 controls. The cases will be women older than 21 years, residents of six counties in New Jersey, with newly diagnosed, histologically confirmed epithelial endometrial cancer. The controls will be frequency matched to the cases (+5years) and selected by random digit dialing (for those under 65) or from HCFA files (for those older than 65 years). The proposed project expands the objectives of the parent grant, whose main goals are to evaluate the role of estrogens, genetics, and dietary fat. The specific aims of the proposed project are to investigate the association between phytoestrogen and alcohol consumption and endometrial cancer risk. Possible effect modification by body mass index, estrogen replacement therapy, fat and total energy intake, smoking, genotypes for enzymes involved in estrogen metabolism, and histologic type will be investigated. Interactions between alcohol and phytoestrogen intakes will also be examined. An additional component of the proposed research is a feasibility study to evaluate an innovative multi-media web-based dietary assessment method, the Computer-Assisted Self-Interview Diet History, in the context of the case-control study of endometrial cancer. This award will provide the support and training the Candidate needs to develop an independent career in the nutritional epidemiology of cancer.