Modelling in-vitro host-parasite infection

简要描述研究背景，包括潜在影响：目前在宿主-寄生虫感染中机械和化学刺激作用的知识差距。这对开发新的更好的寄生虫病治疗方法产生了连锁反应，因为目前的药物测试是在与体内条件（培养皿底部的细胞）完全不同的环境中进行的。对设计新的更现实的体外系统来测试抗寄生虫感染药物的潜在影响。目的和目标：当暴露于一系列不同的化学和机械刺激时，数学模型宿主-寄生虫相互作用。在体内药物测试系统的背景下考虑这一点，以及操作条件如何影响相互作用。提出比当前方法更现实的更好的体外测试条件的建议研究方法的新颖性：通过开发描述发挥作用的过程的新颖数学模型来解决已确定的知识差距。与研究委员会的战略和研究领域保持一致：数学科学-连续介质力学，数学生物学，流体力学医疗保健技术物理科学-生物物理学和软物质物理学卫生国家任何参与的公司或合作者：实验合作者。

Brief description of the context of the research including potential impact:Current knowledge gap in role of mechanical and chemical stimuli in host-parasite infection. This has a knock-on effect in developing new and better treatments for parasitic diseases since current testing of drugs takes place in environments that are quite different from in-vivo conditions (cells at the bottom of a dish). Potential impact in designing new more realistic in-vitro systems for testing drugs against parasitic infections.Aims and objectives:Mathematically model host-parasite interactions when exposed to a range of different chemical and mechanical stimuli. Consider this in the context of in vivo drug testing systems and how the operating conditions may influence the interactions. Make suggestions for better in vitro testing conditions that are more realistic than the current approachNovelty of the research methodology:Addressing the identified knowledge gap through the development of novel mathematical models describing the processes at play.Alignment to Research Council's strategies and research areas:Mathematical Sciences - Continuum mechanics, mathematical biology, fluid mechanicsHealthcare Technologies Physical Sciences - Biophysics and soft matter physicsHealth NationAny companies or collaborators involved:Experimental collaborators.