Imaging regional physiologic parameters of lung function

描述(申请人提供)：肺部成像技术传统上强调对肺实质、呼吸道和血管系统的解剖和病理的描述。功能肺成像的最新进展，特别是超极化(HP)3He磁共振成像，引起了人们对它们改进这些传统技术所取得的结果的兴趣。这项提议的目标是实施新的HP 3He MRI技术，以生成描述肺功能的局部参数的生理地图。这一建议的中心假设是，描述肺功能的区域生理参数(即区域通气量、区域灌注量、灌流效率指数、区域肺泡氧分压、区域VA/Q)的HP 3He MRI图将比现有的成像方式更准确地发现病变肺的早期功能和结构变化。我们将通过建立以下具体目标来验证我们的假设：1)测量健康的约克夏猪和通风增加异常的猪的区域通气量，2)测量健康的约克夏猪和不同区域通风和/或灌流异常的猪的肺局部氧分压，3)测量健康的约克夏猪和接受血管收缩治疗的猪的区域灌注量和区域灌注率指数，以及4)获得健康的约克夏猪和通风和灌流异常的猪的区域VA/Q。这项工作将有助于实现检测和治疗许多肺部疾病的特定标记物的关键。我们的技术将更准确地描绘与肺部疾病相关的结构和功能变化。

DESCRIPTION (provided by applicant): Pulmonary imaging techniques have traditionally emphasized the description of the anatomy and pathology of the lung parenchyma, airways, and vasculature. Recent developments in functional lung imaging and, in particular, hyperpolarized (HP) 3He MRI have generated interest for their ability to improve upon the results attained by these traditional techniques. The goal of this proposal is to implement the novel HP 3He MRI technique to generate physiological maps of regional parameters that describe lung function. The central hypothesis of this proposal is that HP 3He MRI maps of regional physiological parameters that describe lung function (i.e., regional ventilation, regional perfusion, perfusion efficiency index, regional alveolar partial pressure of oxygen, regional VA/Q) will more accurately detect early functional and structural changes in a diseased lung than existing imaging modalities. We will test our hypothesis by establishing the following specific aims: 1) To measure regional ventilation in healthy Yorkshire pigs and in pigs with increasing ventilation abnormality, 2) To measure the regional lung partial pressure of oxygen in healthy Yorkshire pigs and in pigs with varying regional ventilation and/or perfusion abnormality, 3) To measure the regional perfusion and the regional perfusion efficiency index in healthy Yorkshire pigs and in pigs that have been administered vasoconstrictor therapy, and 4) To obtain the regional VA/Q in healthy Yorkshire pigs and in pigs with increasing ventilation and perfusion abnormalities. This work will contribute towards the pivotal implementation of specific markers for the detection of and therapy for many pulmonary disorders. Our technique will delineate with greater accuracy the structural and functional changes associated with pulmonary diseases.