Vaginal Microbicide Acceptability STD/HIV Prevention

描述（由申请人提供）：这是一个修改后的应用程序。这项研究的主要目的是探讨与阴道杀微生物剂可接受性相关的因素。样本将从青春期中后期的高危女性中抽取。研究分为两个阶段。第一阶段将包括焦点小组、个人访谈和性二对访谈，以确定感兴趣的相关方面，并了解文化影响和适当的语言。第2阶段将包括评估阴道杀微生物剂用于预防性传播疾病的可接受性的各个方面（在第1阶段开发）的相对重要性。从市场研究的角度来看，概念测试被选为评估试用某种杀微生物剂的可能性的最佳方法。可接受性是指尝试具有特定特性的假设杀微生物剂的意图。该理论框架改编自计划行为理论。其他结构将从创新扩散理论中得出。行为意图将使用一系列视频短片进行评估，以模拟真实生活中的性决策场景。修订后的应用程序包括对拟议方法的技术可行性进行试点演示。分析将侧重于与可接受性相关的产品特征、与接受性相关的态度和社会规范，以及基于初始可接受性估计的实际使用预测。一个由青少年医学、心理学和营销学组成的多学科小组被召集起来进行研究。该小组在青少年性行为、性传播疾病和接受性传播疾病相关疫苗等主题的临床和营销研究方面经验丰富。

DESCRIPTION (provided by applicant): This is a revised application. The primary goal of the proposed research is to explore factors associated with vaginal microbicides acceptability. The sample will be drawn from high-risk women in middle and late adolescence. The research is organized into two phases. Phase 1 will consist of focus groups, individual interviews and sexual dyad interviews in order to identify relevant dimensions of interest as well as develop understanding of cultural influences and appropriate language. Phase 2 will consist of an assessment of the relative importance of the various dimensions (developed in Phase 1) on acceptability of vaginal microbicide use for STD prevention. Drawing from the perspective of marketing research, a concept test is chosen as the best methodology to assess the likelihood of a trial of use of a given microbicide. Acceptability is operationalized as intention to try a hypothetical microbicide with specified characteristics. The theoretical framework is adapted from the Theory of Planned Behavior. Additional constructs will be drawn from Diffusion of Innovation Theory. Behavioral intention will be assessed using a series of video vignettes in order to simulate real-life scenarios of sexual decision-making. The revised application includes pilot demonstration of technical feasibility of the proposed approach. Analyses will focus on product characteristics associated with acceptability, attitudes and social norms associated with acceptance and forecasting of actual use based on initial acceptability estimates. A multi-disciplinary team drawn from adolescent medicine, psychology and marketing is assembled to conduct the research. This team is substantially experienced in conducting clinical and marketing research with adolescents addressing topics of sexual behavior, sexually transmitted diseases and acceptance of STD-related vaccines.